Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.57 |
| ▸ | SCN10A | Q9Y5Y9 | 8/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | GCK | P35557 | 4/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6169601 | 0.99 | PTGS2 (0.58) | PTGS2PTGS1SCN10AKDM4EHPGD | |
| SCHEMBL6170721 | 0.89 | PTGS2 (0.51) | PTGS2PTGS1SCN10AGCKNR1H2 | |
| SCHEMBL6170360 | 0.89 | PIK3CA (0.51) | PTGS2PTGS1GCKNR1H2NR1H3 | |
| SCHEMBL6171043 | 0.88 | PTGS2 (0.71) | PTGS2PTGS1SCN10AGCK | |
| SCHEMBL6168591 | 0.88 | PTGS2 (0.71) | PTGS2PTGS1SCN10AGCK | |
| SCHEMBL6172316 | 0.87 | PTGS2 (0.51) | PTGS2PTGS1SCN10AGCKNR1H2 | |
| SCHEMBL6169595 | 0.86 | PTGS2 (0.73) | PTGS2PTGS1SCN10AGCK | |
| SCHEMBL6168390 | 0.85 | PTGS2 (0.47) | PTGS2PTGS1SCN10AGCKNR1H2 | |
| SCHEMBL6169775 | 0.83 | CNR2 (0.44) | PTGS2PTGS1KDM4ENR1H2NR1H3 | |
| SCHEMBL6171795 | 0.83 | PTGS2 (0.51) | PTGS2PTGS1SCN10ANR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1015431-B1 | 2-AMINOPYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2 | MERCK FROSST CANADA INC (CA) | 2005-04-20 | — | — | EP | claimed |
| EP-1015431-A1 | 2-AMINOPYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2 | Merck Frosst Canada & Co. (CA) | 2000-07-05 | — | — | EP | claimed |
| WO-1999014195-A1 | 2-AMINOPYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2 | MERCK FROSST CANADA & CO. (CA) | 1999-03-25 | — | — | WO | claimed |
| EP-1015431-B1 | 2-AMINOPYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2 | MERCK FROSST CANADA INC (CA) | 2005-04-20 | — | — | EP | disclosed |
| EP-1015431-A1 | 2-AMINOPYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2 | Merck Frosst Canada & Co. (CA) | 2000-07-05 | — | — | EP | disclosed |
| US-6004950-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS; ANALGESIC, ANTIPYRETICS; SIDE EFFECT REDUCTION | MERCK FROSST CANADA, INC. (CA) | 1999-12-21 | — | — | US | disclosed |
| WO-1999014195-A1 | 2-AMINOPYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2 | MERCK FROSST CANADA & CO. (CA) | 1999-03-25 | — | — | WO | disclosed |