Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.65 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.49 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.49 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.45 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6167141 | 0.93 | MAPK14 (0.67) | MAPK14MAPK13MAPK12MAPK11MAPT | |
| SCHEMBL6167786 | 0.83 | MAPK14 (0.62) | MAPK14MAPK13MAPK12MAPK11MAPT | |
| SCHEMBL6167060 | 0.81 | MAPK14 (0.62) | MAPK14MAPK13MAPK12MAPK11MAPT | |
| SCHEMBL6348042 | 0.80 | MAPK14 (0.88) | MAPK14MAPK13MAPK12MAPK11MAPT | |
| SCHEMBL6348418 | 0.79 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11MAPT | |
| SCHEMBL6166915 | 0.77 | NPC1 (0.58) | MAPK14MAPK13MAPK12MAPK11MAPT | |
| SCHEMBL6165669 | 0.74 | ESR1 (0.60) | MAPK14MAPK13MAPK12MAPK11MAPT | |
| SCHEMBL4419929 | 0.73 | MAPK14 (0.58) | MAPK14MAPK13MAPK12MAPK11BRAF | |
| SCHEMBL4831633 | 0.71 | BRAF (0.56) | MAPK14MAPK13MAPK12MAPK11MAPT | |
| SCHEMBL23964161 | 0.70 | MAPT (0.52) | MAPTTP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1495016-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS MODULATORS OF P38 MAP KINASE | Astex Technology Limited (GB) | 2005-01-12 | — | — | EP | disclosed |
| WO-2003087087-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS MODULATORS OF P38 MAP KINASE | ASTEX TECHNOLOGY LIMITED (GB) | 2003-10-23 | — | — | WO | disclosed |