SCHEMBL23964161

SCHEMBL23964161

O=C(Nc1ccc2[nH]c(CN3CCN(c4ccncc4)CC3)cc2c1)c1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 7/20 0.52
SMN1; SMN2 Q16637 4/20 0.52
MAPK1 P28482 1/20 0.52
MAOA P21397 1/20 0.52
MAOB P27338 1/20 0.52
DRD2 P14416 2/20 0.51
DRD4 P21917 2/20 0.51
DRD3 P35462 2/20 0.51
SLC2A1 P11166 2/20 0.50
HSD17B10 Q99714 4/20 0.48
LMNA P02545 2/20 0.48
USP2 O75604 1/20 0.48
ALDH1A1 P00352 1/20 0.48
HPGD P15428 1/20 0.48
KDM4E B2RXH2 2/20 0.47
NPC1 O15118 2/20 0.47
RAB9A P51151 2/20 0.47
JAK2 O60674 1/20 0.47
TP53 P04637 1/20 0.46
TSHR P16473 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23932585 0.91 DRD2 (0.51) MAPTSMN1; SMN2MAPK1DRD2DRD4
SCHEMBL30042174 0.91 DRD2 (0.51) MAPTSMN1; SMN2MAPK1DRD2DRD4
SCHEMBL23964226 0.86 DRD2 (0.47) MAPTSMN1; SMN2DRD2DRD4DRD3
SCHEMBL30041347 0.86 DRD2 (0.47) MAPTSMN1; SMN2DRD2DRD4DRD3
SCHEMBL23964250 0.82 DRD2 (0.53) DRD2DRD4DRD3SLC2A1HTR1A
SCHEMBL23964166 0.79 DRD4 (0.59) DRD2DRD4DRD3SLC2A1HTR1A
SCHEMBL23964263 0.79 DRD2 (0.47) SMN1; SMN2MAOADRD2DRD4DRD3
SCHEMBL30041863 0.79 DRD2 (0.47) SMN1; SMN2MAOADRD2DRD4DRD3
SCHEMBL25202850 0.79 PDGFRB (0.47) SMN1; SMN2MAPK1DRD2DRD4DRD3
SCHEMBL23964200 0.78 HRH4 (0.63) DRD2DRD4DRD3HTR1AADRA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119775261-A Collagen 1 translation inhibitors and methods of use thereof 艾尼莫生物科技公司 2025-04-08 CN disclosed
CN-115427404-B Collagen 1 translation inhibitors and methods of use thereof 艾尼莫生物科技公司 2024-12-13 CN disclosed
US-20230150980-A1 COLLAGEN 1 TRANSLATION INHIBITORS AND METHODS OF USE THEREOF ANIMA BIOTECH INC. (US) 2023-05-18 US disclosed
US-20230150980-A1 COLLAGEN 1 TRANSLATION INHIBITORS AND METHODS OF USE THEREOF ANIMA BIOTECH INC. (US) 2023-05-18 US disclosed
EP-4139291-A1 COLLAGEN 1 TRANSLATION INHIBITORS AND METHODS OF USE THEREOF Anima Biotech Inc. (US) 2023-03-01 EP disclosed
CN-115427404-A Collagen 1 translation inhibitors and methods of use thereof 艾尼莫生物科技公司 2022-12-02 CN disclosed
WO-2021216665-A9 COLLAGEN 1 TRANSLATION INHIBITORS AND METHODS OF USE THEREOF ANIMA BIOTECH INC. (US) 2021-12-02 WO disclosed
WO-2021216665-A1 COLLAGEN 1 TRANSLATION INHIBITORS AND METHODS OF USE THEREOF ANIMA BIOTECH INC. (US) 2021-10-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230150980-A1 COLLAGEN 1 TRANSLATION INHIBITORS AND METHODS OF USE THEREOF COL1A1, COL2A1, COL14A1 MAPT 3388/4885SMN1; SMN2 1307/4885MAPK1 944/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.