Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.60 |
| ▸ | CA2 | P00918 | 3/20 | 0.60 |
| ▸ | TSHR | P16473 | 3/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.54 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA3 | P07451 | 1/20 | 0.50 |
| ▸ | TYR | P14679 | 1/20 | 0.50 |
| ▸ | DRD1 | P21728 | 1/20 | 0.50 |
| ▸ | CA4 | P22748 | 1/20 | 0.50 |
| ▸ | CA6 | P23280 | 1/20 | 0.50 |
| ▸ | CA5A | P35218 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.50 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6746609 | 0.79 | TSHR (0.67) | CA1CA2TSHRTP53PARP15 | |
| Terephthalic Acid SCHEMBL9861713 | 0.79 | PARP10 (0.78) | CA1CA2TSHRTP53PARP15 | |
| SCHEMBL766069 | 0.79 | PARP10 (0.78) | CA1CA2TSHRTP53PARP15 | |
| SCHEMBL5581520 | 0.79 | PARP10 (0.78) | CA1CA2TSHRTP53PARP15 | |
| SCHEMBL22281 | 0.79 | PARP10 (0.78) | CA1CA2TSHRTP53PARP15 | |
| SCHEMBL7138100 | 0.78 | PARP10 (0.67) | CA1CA2PARP15PARP10KMT2A | |
| SCHEMBL2094120 | 0.78 | MAPT (0.67) | KMT2AALDH1A1L3MBTL1SMN1; SMN2LMNA | |
| Terephthalic Acid SCHEMBL210852 | 0.78 | TSHR (0.86) | CA1CA2TSHRTP53SRD5A2 | |
| Terephthalic Acid SCHEMBL1194495 | 0.78 | TSHR (0.86) | CA1CA2TSHRTP53SRD5A2 | |
| Terephthalic Acid SCHEMBL17628648 | 0.78 | TSHR (0.86) | CA1CA2TSHRTP53SRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1528059-A2 | Substituted isoxazoles for the treatment of inflammation | G.D. Searle LLC (US) | 2005-05-04 | — | — | EP | claimed |
| EP-1223167-A2 | Substituted isoxazoles for the treatment of inflammation | G.D. Searle & Co. (US) | 2002-07-17 | — | — | EP | claimed |
| EP-0809636-A1 | SUBSTITUTED ISOXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-12-03 | — | — | EP | claimed |
| WO-1996025405-A1 | SUBSTITUTED ISOXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-08-22 | — | — | WO | claimed |
| EP-1528059-A2 | Substituted isoxazoles for the treatment of inflammation | G.D. Searle LLC (US) | 2005-05-04 | — | — | EP | disclosed |
| EP-1144365-B1 | INHIBITORS OF ALPHA-4 BETA-1 MEDIATED CELL ADHESION | TANABE SEIYAKU CO (JP) | 2004-03-17 | — | — | EP | disclosed |
| EP-1144365-A3 | INHIBITORS OF ALPHA-4 BETA-1 MEDIATED CELL ADHESION | TANABE SEIYAKU CO., LTD. (JP) | 2003-07-09 | — | — | EP | disclosed |
| EP-1223167-A2 | Substituted isoxazoles for the treatment of inflammation | G.D. Searle & Co. (US) | 2002-07-17 | — | — | EP | disclosed |
| EP-1144365-A2 | INHIBITORS OF ALPHA-4 BETA-1 MEDIATED CELL ADHESION | TANABE SEIYAKU CO., LTD. (JP) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000037429-A2 | INHIBITORS OF α4β1 MEDIATED CELL ADHESION | TANABE SEIYAKU CO., LTD. (JP) | 2000-06-29 | — | — | WO | disclosed |
| US-5859257-A | ANTIINFLAMMATORY, ANTIARTHRITIC AGENTS | G. D. SEARLE & CO. (US) | 1999-01-12 | — | — | US | disclosed |
| CN-1169441-A | Aromatic polycarbodiimide and sheet using it | NITTO DENKO CORP (JP) | 1998-01-07 | — | — | CN | disclosed |
| US-4324890-A | ANTIBIOTICS, BACTERICIDES | MERCK & CO., INC. (US) | 1982-04-13 | — | — | US | disclosed |
| US-4297488-A | 7-α-Methoxy cephalosporins | MERCK & CO., INC. (US) | 1981-10-27 | — | — | US | disclosed |
| US-4255423-A | BACTERICIDES | MERCK & CO., INC. (US) | 1981-03-10 | — | — | US | disclosed |
| US-4154845-A | ANTIBIOTIC, BACTERICIDE | MERCK & CO., INC. (US) | 1979-05-15 | — | — | US | disclosed |
| US-4086423-A | CEPHALOSPORINS, CYCLOADDITION OF GLYCINE DERIVATIVE TO THIAZINE COMPOUND | MERCK & CO., INC. (US) | 1978-04-25 | — | — | US | disclosed |
| US-4071529-A | Derivatives of 6-aminopenicillanic acid | MERCK & CO., INC. (US) | 1978-01-31 | — | — | US | disclosed |
| US-4064344-A | ANTIBIOTIC | MERCK & CO., INC. (US) | 1977-12-20 | — | — | US | disclosed |
| US-3974151-A | Cephalosporin compounds | MERCK & CO., INC. (US) | 1976-08-10 | — | — | US | disclosed |