Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.33 |
| ▸ | AKT1 | P31749 | 2/20 | 0.32 |
| ▸ | MTOR | P42345 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.30 |
| ▸ | SMO | Q99835 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10236654 | 0.87 | DGAT1 (0.37) | MAT2APIK3CAAKT1MTORHSD17B10 | |
| SCHEMBL2679335 | 0.87 | DGAT1 (0.37) | MAT2APIK3CAAKT1MTORHSD17B10 | |
| SCHEMBL2679521 | 0.87 | SMO (0.37) | PIK3CAAKT1MTORHSP90AA1SMO | |
| SCHEMBL595034 | 0.85 | DGAT1 (0.41) | MAT2APIK3CAAKT1MTORHSD17B10 | |
| SCHEMBL7883024 | 0.84 | PIK3CA (0.33) | PIK3CAAKT1MTORDGAT1CHEK1 | |
| SCHEMBL1073652 | 0.84 | PIK3CA (0.33) | PIK3CAAKT1MTORCHEK1 | |
| SCHEMBL10239398 | 0.83 | PIK3CA (0.35) | MAT2APIK3CAAKT1MTORHSD17B10 | |
| SCHEMBL10237223 | 0.83 | PIK3CA (0.31) | PIK3CAAKT1MTORDGAT1 | |
| SCHEMBL585081 | 0.83 | JAK2 (0.32) | PIK3CAAKT1MTORDGAT1 | |
| SCHEMBL2679912 | 0.82 | HPGDS (0.38) | KDM4EALDH1A1LMNANPSR1SMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417138-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | Schering Corporation (US) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010118207-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | SCHERING CORPORATION (US) | 2010-10-14 | — | — | WO | disclosed |