Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 15/20 | 0.68 |
| ▸ | CA9 | Q16790 | 15/20 | 0.68 |
| ▸ | CA12 | O43570 | 11/20 | 0.68 |
| ▸ | CA1 | P00915 | 13/20 | 0.60 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.59 |
| ▸ | CA4 | P22748 | 2/20 | 0.59 |
| ▸ | CA6 | P23280 | 2/20 | 0.59 |
| ▸ | CA5A | P35218 | 2/20 | 0.59 |
| ▸ | CA7 | P43166 | 2/20 | 0.59 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.59 |
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.54 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.53 |
| ▸ | PRKCI | P41743 | 1/20 | 0.53 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3720559 | 0.85 | CA2 (0.70) | CA2CA9CA12CA1CA14 | |
| SCHEMBL24721302 | 0.83 | CA2 (0.68) | CA2CA9CA12CA1CA14 | |
| SCHEMBL2025954 | 0.83 | FYN (0.57) | CA2CA9CA12PTGES2ADAMTS4 | |
| SCHEMBL7188667 | 0.83 | PTGES2 (0.64) | CA2CA9CA12CA1CA14 | |
| Biphenyl SCHEMBL2902198 | 0.83 | PTGES2 (0.54) | CA2CA9CA12CA1CA14 | |
| SCHEMBL15560613 | 0.83 | CA2 (0.62) | CA2CA9CA12CA1CA14 | |
| SCHEMBL5893183 | 0.82 | CA2 (0.88) | CA2CA9CA12CA1CA14 | |
| SCHEMBL185757 | 0.80 | CA2 (0.61) | CA2CA9CA12CA1CA14 | |
| SCHEMBL7064867 | 0.80 | PTGS2 (0.68) | CA2CA9CA12CA1CA14 | |
| SCHEMBL18297788 | 0.80 | PRKCI (0.76) | ADAMTS4PRKCIACMSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1528059-A2 | Substituted isoxazoles for the treatment of inflammation | G.D. Searle LLC (US) | 2005-05-04 | — | — | EP | disclosed |
| EP-0809636-B1 | SUBSTITUTED ISOXAZOLES FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2002-09-04 | — | — | EP | disclosed |
| EP-1223167-A2 | Substituted isoxazoles for the treatment of inflammation | G.D. Searle & Co. (US) | 2002-07-17 | — | — | EP | disclosed |
| US-5985902-A | TREATING INFLAMMATION AND INFLAMMATION-ASSOCIATED DISORDERS, SUCH AS ARTHRITIS | G.D. SEARLE & CO. (US) | 1999-11-16 | — | — | US | disclosed |
| US-5633272-A | Substituted isoxazoles for the treatment of inflammation | PHARMACIA & UPJOHN COMPANY LLC | 1997-05-27 | — | — | US | disclosed |