Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.36 |
| ▸ | CTSS | P25774 | 2/20 | 0.36 |
| ▸ | CTSK | P43235 | 2/20 | 0.36 |
| ▸ | CTSL | P07711 | 2/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PREP | P48147 | 1/20 | 0.31 |
| ▸ | REN | P00797 | 1/20 | 0.31 |
| ▸ | NPR3 | P17342 | 1/20 | 0.31 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1733549 | 0.80 | KMT2A (0.39) | CTSSCTSKKMT2APREP | |
| SCHEMBL8283016 | 0.78 | AAK1 (0.45) | AAK1HDAC4HDAC1HDAC6GAA | |
| SCHEMBL14513393 | 0.78 | AAK1 (0.45) | AAK1HDAC4HDAC1HDAC6GAA | |
| SCHEMBL2724209 | 0.76 | AAK1 (0.42) | AAK1HDAC4HDAC1HDAC6GAA | |
| SCHEMBL23005710 | 0.75 | CTSS (0.47) | AAK1HDAC4HDAC1HDAC6GAA | |
| SCHEMBL844823 | 0.75 | CTSS (0.47) | AAK1HDAC4HDAC1HDAC6GAA | |
| SCHEMBL22285128 | 0.75 | CTSS (0.47) | AAK1HDAC4HDAC1HDAC6GAA | |
| SCHEMBL22285129 | 0.75 | CTSS (0.47) | AAK1HDAC4HDAC1HDAC6GAA | |
| SCHEMBL22125910 | 0.75 | CTSS (0.47) | AAK1HDAC4HDAC1HDAC6GAA | |
| SCHEMBL16317185 | 0.75 | GAA (0.47) | AAK1HDAC4HDAC1HDAC6GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465891-A4 | INHIBITORS OF DIPEPTIDYL PEPTIDASE IV | GUILFORD PHARM INC (US) | 2005-08-17 | — | — | EP | disclosed |
| EP-1465891-A2 | INHIBITORS OF DIPEPTIDYL PEPTIDASE IV | GUILFORD PHARMACEUTICALS INC. (US) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003057666-A2 | INHIBITORS OF DIPEPTIDYL PEPTIDASE IV | GUILFORD PHARMACEUTICALS (US) | 2003-07-17 | — | — | WO | disclosed |
| WO-2003057144-A2 | CHANGE INHIBITORS OF DIPEPTIDYL PEPTIDASE IV | GUILFORD PHARMACEUTICALS (US) | 2003-07-17 | — | — | WO | disclosed |