Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CRHR1 | P34998 | 9/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | EHMT2 | Q96KQ7 | 3/20 | 0.32 |
| ▸ | EHMT1 | Q9H9B1 | 3/20 | 0.32 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6167662 | 0.96 | ALDH1A1 (0.39) | ALDH1A1HPGDTSHRKDM4EHSD17B10 | |
| SCHEMBL6166551 | 0.85 | KDM4E (0.43) | ALDH1A1HPGDTSHRKDM4EHSD17B10 | |
| SCHEMBL6168569 | 0.83 | CRHR1 (0.54) | CRHR1 | |
| SCHEMBL6168203 | 0.81 | KDM4E (0.43) | ALDH1A1HPGDTSHRKDM4EHSD17B10 | |
| SCHEMBL6167259 | 0.80 | CRHR1 (0.44) | ALDH1A1HPGDTSHRKDM4EHSD17B10 | |
| SCHEMBL6165056 | 0.79 | CRHR1 (0.43) | ALDH1A1HPGDTSHRKDM4EHSD17B10 | |
| SCHEMBL6168196 | 0.79 | KDM4E (0.42) | ALDH1A1HPGDTSHRKDM4EHSD17B10 | |
| SCHEMBL6167659 | 0.79 | CRHR1 (0.54) | CRHR1 | |
| SCHEMBL6169758 | 0.79 | CRHR1 (0.40) | ALDH1A1HPGDTSHRKDM4EHSD17B10 | |
| SCHEMBL6166934 | 0.77 | CRHR1 (0.61) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499599-A1 | SUBSTITUTED PYRAZINE DERIVATIVES | Pharmacia & Upjohn Company LLC (US) | 2005-01-26 | — | — | EP | disclosed |
| WO-2003091225-A1 | SUBSTITUTED PYRAZINE DERIVATIVES | PHARMACIA & UPJOHN COMPANY (US) | 2003-11-06 | — | — | WO | disclosed |