Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 6/20 | 0.39 |
| ▸ | AR | P10275 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | TRPV3 | Q8NET8 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6175073 | 0.90 | IGF1R (0.38) | IGF1RARKMT2ATRPV3LMNA | |
| SCHEMBL6173200 | 0.88 | KMT2A (0.37) | IGF1RARKMT2ATRPV3LMNA | |
| SCHEMBL6203204 | 0.86 | IGF1R (0.40) | IGF1RARKMT2ATRPV3LMNA | |
| SCHEMBL6175857 | 0.86 | KMT2A (0.36) | IGF1RARKMT2ATRPV3LMNA | |
| SCHEMBL6175269 | 0.86 | MAPT (0.40) | IGF1RARKMT2ATRPV3THRB | |
| SCHEMBL6174238 | 0.85 | KDM4E (0.42) | IGF1RARKMT2ATRPV3LMNA | |
| SCHEMBL6174561 | 0.85 | IGF1R (0.40) | IGF1RARKMT2ATSHRMAPK1 | |
| SCHEMBL6173508 | 0.85 | IGF1R (0.56) | IGF1RAR | |
| SCHEMBL6201343 | 0.84 | PTGS2 (0.40) | IGF1RARKMT2ATRPV3LMNA | |
| SCHEMBL6177630 | 0.84 | IGF1R (0.39) | IGF1RARKMT2ATRPV3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |