Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | IGF1R | P08069 | 3/20 | 0.39 |
| ▸ | AR | P10275 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6177630 | 0.88 | IGF1R (0.39) | IGF1RARKMT2ATHRBMAPT | |
| SCHEMBL6175911 | 0.87 | THRB (0.38) | PTGS2IGF1RARKMT2ATHRB | |
| SCHEMBL6175073 | 0.87 | IGF1R (0.38) | IGF1RARKMT2ATHRBMAPT | |
| SCHEMBL6203204 | 0.87 | IGF1R (0.40) | IGF1RARKMT2ATHRBMAPT | |
| SCHEMBL6175022 | 0.86 | IGF1R (0.40) | PTGS2IGF1RARKMT2ATHRB | |
| SCHEMBL6172914 | 0.86 | IGF1R (0.38) | PTGS2IGF1RARKMT2ATHRB | |
| SCHEMBL6207888 | 0.86 | IGF1R (0.40) | IGF1RARKMT2ATHRBCYP2C9 | |
| SCHEMBL6174119 | 0.85 | PTGS2 (0.37) | PTGS2IGF1RARKMT2ATHRB | |
| SCHEMBL6174586 | 0.84 | TP53 (0.39) | PTGS2IGF1RARKMT2ATP53 | |
| SCHEMBL6171849 | 0.84 | IGF1R (0.39) | IGF1RARKMT2ACYP2C9TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |