Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18618085 | 0.84 | LMNA (0.40) | HTR2CHPGDHSD17B10RPS6KA3OPRL1 | |
| SCHEMBL68378 | 0.81 | HSP90AA1 (0.44) | HSP90AA1HTR2CHPGDTSHRHSD17B10 | |
| SCHEMBL614971 | 0.78 | RPS6KA3 (0.44) | RPS6KA3OPRL1DAO | |
| SCHEMBL16736883 | 0.74 | HTR2C (0.35) | HSP90AA1HTR2CHPGDTSHRHSD17B10 | |
| SCHEMBL5216028 | 0.73 | QDPR (0.43) | TSHRHSD17B10OPRL1 | |
| SCHEMBL614735 | 0.72 | PIK3CD (0.42) | HSP90AA1HPGDHSD17B10RPS6KA3OPRL1 | |
| SCHEMBL29429338 | 0.72 | PIK3CD (0.42) | HSP90AA1HPGDHSD17B10RPS6KA3OPRL1 | |
| SCHEMBL18587275 | 0.69 | LMNA (0.46) | HTR2CHPGDHSD17B10DRD2DRD1 | |
| SCHEMBL18587191 | 0.69 | GAA (0.42) | HPGDTSHRHSD17B10DRD2DRD1 | |
| SCHEMBL29588427 | 0.69 | LMNA (0.46) | HTR2CHPGDHSD17B10DRD2DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016102400-A1 | COMPOSITION COMPRISING A 4-(HETEROCYCLOALKYL)-BENZENE-1,3-DIOL COMPOUND AND A SPECIFIC SOLVENT | L'OREAL (FR) | 2016-06-30 | — | — | WO | claimed |
| WO-2016102402-A1 | AQUEOUS COMPOSITION COMPRISING A 4-(HETEROCYCLOALKYL)-BENZENE-1,3-DIOL COMPOUND, A C2-C4 MONOALCOHOL, AND A GLYCOL | L'OREAL (FR) | 2016-06-30 | — | — | WO | claimed |
| WO-2016102398-A1 | AQUEOUS COMPOSITION COMPRISING A 4-(HETEROCYCLOALKYL)-BENZENE-1,3-DIOL COMPOUND, A POLYMER AND A GLYCOL | L'OREAL (FR) | 2016-06-30 | — | — | WO | claimed |
| WO-2016102399-A1 | AQUEOUS COMPOSITION COMPRISING A 4-(HETEROCYCLOALKYL)-BENZENE-1,3-DIOL COMPOUND AND A HYDROTROPE | L'OREAL (FR) | 2016-06-30 | — | — | WO | claimed |
| EP-2529735-B1 | COMPOSITIONS COMPRISING 4-(HETEROCYCLOALKYL)BENZENE-1,3-DIOL DERIVATIVES WITH TYROSINASE ENZYME INHIBITING ACTIVITY | GALDERMA RES & DEV (FR) | 2014-06-25 | — | — | EP | claimed |
| US-8372879-B2 | 4-(heterocycloalkyl) benzene-1,3-diol compounds as tyrosinase inhibitors, process for the preparation thereof and use thereof in human medicine and also in cosmetics | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2013-02-12 | — | — | US | claimed |
| EP-2529735-A1 | Novel 4-(heterocycloalkyl)benzene-1,3-diol compounds as tyrosinase inhibitors, process for the preparation thereof and use thereof in human medicine and also in cosmetics | Galderma Research & Development (FR) | 2012-12-05 | — | — | EP | claimed |
| EP-2373310-B1 | NOVEL 4-(HETEROCYCLOALKYL)BENZENE-1,3-DIOL COMPOUNDS AS TYROSINASE INHIBITORS, PROCESS FOR THE PREPARATION THEREOF AND USE THEREOF IN HUMAN MEDICINE AND ALSO IN COSMETICS | GALDERMA RES & DEV (FR) | 2012-10-10 | — | — | EP | claimed |
| US-20120041213-A1 | 4-(HETEROCYCLOALKYL) BENZENE -1,3-DIOL COMPOUNDS AS TYROSINASE INHIBITORS, PROCESS FOR THE PREPARATION THEREOF AND USE THEREOF IN HUMAN MEDICINE AND ALSO IN COSMETICS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2012-02-16 | — | — | US | claimed |
| EP-2373310-A1 | NOVEL 4-(HETEROCYCLOALKYL)BENZENE-1,3-DIOL COMPOUNDS AS TYROSINASE INHIBITORS, PROCESS FOR THE PREPARATION THEREOF AND USE THEREOF IN HUMAN MEDICINE AND ALSO IN COSMETICS | Galderma Research & Development (FR) | 2011-10-12 | — | — | EP | claimed |
| WO-2010063773-A1 | NOVEL 4-(HETEROCYCLOALKYL)BENZENE-1,3-DIOL COMPOUNDS AS TYROSINASE INHIBITORS, PROCESS FOR THE PREPARATION THEREOF AND USE THEREOF IN HUMAN MEDICINE AND ALSO IN COSMETICS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2010-06-10 | — | — | WO | claimed |
| WO-2016102400-A1 | COMPOSITION COMPRISING A 4-(HETEROCYCLOALKYL)-BENZENE-1,3-DIOL COMPOUND AND A SPECIFIC SOLVENT | L'OREAL (FR) | 2016-06-30 | — | — | WO | disclosed |
| WO-2016102402-A1 | AQUEOUS COMPOSITION COMPRISING A 4-(HETEROCYCLOALKYL)-BENZENE-1,3-DIOL COMPOUND, A C2-C4 MONOALCOHOL, AND A GLYCOL | L'OREAL (FR) | 2016-06-30 | — | — | WO | disclosed |
| WO-2016102399-A1 | AQUEOUS COMPOSITION COMPRISING A 4-(HETEROCYCLOALKYL)-BENZENE-1,3-DIOL COMPOUND AND A HYDROTROPE | L'OREAL (FR) | 2016-06-30 | — | — | WO | disclosed |
| WO-2016102398-A1 | AQUEOUS COMPOSITION COMPRISING A 4-(HETEROCYCLOALKYL)-BENZENE-1,3-DIOL COMPOUND, A POLYMER AND A GLYCOL | L'OREAL (FR) | 2016-06-30 | — | — | WO | disclosed |
| EP-2529735-A1 | Novel 4-(heterocycloalkyl)benzene-1,3-diol compounds as tyrosinase inhibitors, process for the preparation thereof and use thereof in human medicine and also in cosmetics | Galderma Research & Development (FR) | 2012-12-05 | — | — | EP | disclosed |
| EP-2373310-B1 | NOVEL 4-(HETEROCYCLOALKYL)BENZENE-1,3-DIOL COMPOUNDS AS TYROSINASE INHIBITORS, PROCESS FOR THE PREPARATION THEREOF AND USE THEREOF IN HUMAN MEDICINE AND ALSO IN COSMETICS | GALDERMA RES & DEV (FR) | 2012-10-10 | — | — | EP | disclosed |
| US-20120041213-A1 | 4-(HETEROCYCLOALKYL) BENZENE -1,3-DIOL COMPOUNDS AS TYROSINASE INHIBITORS, PROCESS FOR THE PREPARATION THEREOF AND USE THEREOF IN HUMAN MEDICINE AND ALSO IN COSMETICS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2012-02-16 | — | — | US | disclosed |
| EP-2373310-A1 | NOVEL 4-(HETEROCYCLOALKYL)BENZENE-1,3-DIOL COMPOUNDS AS TYROSINASE INHIBITORS, PROCESS FOR THE PREPARATION THEREOF AND USE THEREOF IN HUMAN MEDICINE AND ALSO IN COSMETICS | Galderma Research & Development (FR) | 2011-10-12 | — | — | EP | disclosed |
| WO-2010063773-A1 | NOVEL 4-(HETEROCYCLOALKYL)BENZENE-1,3-DIOL COMPOUNDS AS TYROSINASE INHIBITORS, PROCESS FOR THE PREPARATION THEREOF AND USE THEREOF IN HUMAN MEDICINE AND ALSO IN COSMETICS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2010-06-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120041213-A1 | 4-(HETEROCYCLOALKYL) BENZENE -1,3-DIOL COMPOUNDS AS TYROSINASE INHIBITORS, PROCESS FOR THE PREPARATION THEREOF AND USE THEREOF IN HUMAN MEDICINE AND ALSO IN COSMETICS | TYR, DDT, PAH | HSP90AA1 2575/4885HTR2C 2615/4885HPGD 39/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.