Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 2/20 | 0.56 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | BCL2 | P10415 | 3/20 | 0.52 |
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | FBP1 | P09467 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6170355 | 0.84 | ALDH1A1 (0.48) | POLBPKMALDH1A1GAAKMT2A | |
| SCHEMBL3645755 | 0.82 | KMT2A (0.65) | HCAR3ALDH1A1GAAKMT2AMAPT | |
| SCHEMBL6168346 | 0.81 | KMT2A (0.51) | ALDH1A1KMT2ALMNAHPGDNPC1 | |
| SCHEMBL6170460 | 0.80 | FLT1 (0.47) | POLBALDH1A1GAAKMT2ABCL2 | |
| SCHEMBL6169439 | 0.80 | KMT2A (0.50) | ALDH1A1KMT2ALMNAHPGDNPC1 | |
| SCHEMBL11150919 | 0.79 | HCAR3 (0.63) | HCAR3ALDH1A1KMT2AMAPTNPSR1 | |
| SCHEMBL3613079 | 0.78 | HCAR3 (0.72) | HCAR3KMT2AMAPTNPSR1 | |
| SCHEMBL6171844 | 0.78 | MAPK1 (0.59) | GAAKMT2ABCL2BCL2L1MCL1 | |
| SCHEMBL14106469 | 0.77 | KMT2A (0.56) | ALDH1A1GAAKMT2ABCL2BCL2L1 | |
| SCHEMBL6168841 | 0.77 | KMT2A (0.57) | POLBPKMHCAR3ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882718-B1 | BENZIMIDAZOLE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO (JP) | 2005-08-31 | — | — | EP | disclosed |
| US-6352985-B1 | CARDIOVASCULAR DISORDERS OR GASTROINTESTINAL DISORDERS, DIABETES (TYPE II DIABETES), DIABETIC COMPLICATIONS METHOD FOR LOWERING THE BLOOD SUGAR LEVEL OF A PATIENT, | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-03-05 | — | — | US | disclosed |
| US-6166219-A | Benzimidazole derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-12-26 | — | — | US | disclosed |
| EP-0882718-A1 | BENZIMIDAZOLE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-12-09 | — | — | EP | disclosed |