Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCP | P55072 | 5/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | HTT | P42858 | 3/20 | 0.62 |
| ▸ | SYK | P43405 | 2/20 | 0.62 |
| ▸ | EGFR | P00533 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.62 |
| ▸ | GALR2 | O43603 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | TUBB4A | P04350 | 4/20 | 0.59 |
| ▸ | TUBB | P07437 | 4/20 | 0.59 |
| ▸ | TUBA3C | P0DPH7 | 4/20 | 0.59 |
| ▸ | TUBA1B | P68363 | 4/20 | 0.59 |
| ▸ | TUBA4A | P68366 | 4/20 | 0.59 |
| ▸ | TUBB4B | P68371 | 4/20 | 0.59 |
| ▸ | TUBB3 | Q13509 | 4/20 | 0.59 |
| ▸ | TUBB2A | Q13885 | 4/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6169341 | 1.00 | VCP (0.68) | VCPALDH1A1HTTSYKEGFR | |
| SCHEMBL21693980 | 0.89 | VCP (0.59) | VCPALDH1A1HTTSYKEGFR | |
| SCHEMBL21693983 | 0.89 | VCP (0.59) | VCPALDH1A1HTTSYKEGFR | |
| SCHEMBL25178513 | 0.86 | VCP (0.68) | VCPALDH1A1HTTSYKEGFR | |
| SCHEMBL26980006 | 0.85 | VCP (0.59) | VCPALDH1A1HTTSYKEGFR | |
| SCHEMBL11229392 | 0.84 | VCP (0.69) | VCPALDH1A1HTTSYKEGFR | |
| SCHEMBL25196775 | 0.84 | VCP (0.66) | VCPALDH1A1HTTSYKEGFR | |
| SCHEMBL30302242 | 0.83 | LMNA (0.59) | VCPALDH1A1HTTSYKEGFR | |
| SCHEMBL27389730 | 0.83 | LMNA (0.59) | VCPALDH1A1HTTSYKEGFR | |
| SCHEMBL26980154 | 0.82 | VCP (0.55) | VCPALDH1A1HTTSYKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111116613-B | Polysubstituted benzimidazole thiazole and derivative and synthesis method thereof | 湘潭大学 | 2021-04-23 | — | — | CN | claimed |
| CN-111116613-B | Polysubstituted benzimidazole thiazole and derivative and synthesis method thereof | 湘潭大学 | 2021-04-23 | — | — | CN | disclosed |
| CN-111116613-A | Polysubstituted benzimidazole thiazole and derivative and synthesis method thereof | 湘潭大学 | 2020-05-08 | — | — | CN | disclosed |
| US-20050187264-A1 | Phosphodiesterase iv inhibitor containing pyridylacrylamide derivative | TSUMURA & CO. (JP) | 2005-08-25 | — | — | US | disclosed |
| EP-1495757-A1 | PHOSPHODIESTERASE IV INHIBITOR CONTAINING PYRIDYLACRYLAMIDE DERIVATIVE | TSUMURA & CO. (JP) | 2005-01-12 | — | — | EP | disclosed |
| US-6313153-B1 | ADMINISTERING PYRIDYLACRYLAMIDE COMPOUND FOR THERAPY OF NEPHRITIS | TSUMURA & CO. (JP) | 2001-11-06 | — | — | US | disclosed |
| EP-1000935-A1 | PYRIDYLACRYLAMIDE DERIVATIVES AND NEPHRITIS REMEDIES AND TGF-$g(b) INHIBITORS CONTAINING THE SAME | TSUMURA & CO. (JP) | 2000-05-17 | — | — | EP | disclosed |
| WO-1988003147-A1 | SELECTED N6-SUBSTITUTED ADENOSINES HAVING SELECTIVE A2 BINDING ACTIVITY | WARNER-LAMBERT COMPANY (US) | 1988-05-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050187264-A1 | Phosphodiesterase iv inhibitor containing pyridylacrylamide derivative | PDE3B, PDE3A, PDE2A | VCP 4766/4885ALDH1A1 245/4885HTT 4488/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.