SCHEMBL6169409

SCHEMBL6169409

CSc1cc(-c2ccc(F)cc2)nn1C(C=O)N1CCN(c2ccc(F)cc2)CC1

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 1/20 0.41
KMT2A Q03164 3/20 0.39
MEN1 O00255 2/20 0.39
MAPT P10636 7/20 0.37
LMNA P02545 3/20 0.37
SMN1; SMN2 Q16637 3/20 0.37
ALDH1A1 P00352 1/20 0.37
GAA P10253 1/20 0.37
CYP3A4 P08684 1/20 0.35
MMP13 P45452 1/20 0.35
MMP14 P50281 1/20 0.35
TSHR P16473 1/20 0.35
KDM4E B2RXH2 1/20 0.35
RECQL P46063 2/20 0.34
MAPK1 P28482 1/20 0.34
HTT P42858 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
RAB9A P51151 2/20 0.34
NPC1 O15118 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6168244 0.79 MAPT (0.36) HRH3KMT2AMEN1MAPTLMNA
SCHEMBL4304948 0.78 MAPT (0.37) HRH3KMT2AMEN1MAPTLMNA
SCHEMBL27764771 0.75 MAPT (0.39) HRH3KMT2AMAPTLMNASMN1; SMN2
SCHEMBL4016365 0.72 LMNA (0.43) MAPTLMNATSHR
SCHEMBL6168372 0.71 GFER (0.42) KMT2AMEN1MAPTLMNASMN1; SMN2
SCHEMBL4013769 0.71 MAPT (0.40) KMT2AMEN1MAPTLMNAALDH1A1
SCHEMBL3857708 0.71 MAPT (0.48) MAPTLMNASMN1; SMN2ALDH1A1GAA
SCHEMBL3814836 0.71 HSD11B1 (0.41) KMT2AMEN1MAPTLMNASMN1; SMN2
SCHEMBL4310650 0.71 HSD11B1 (0.41) KMT2AMEN1MAPTLMNASMN1; SMN2
SCHEMBL2873762 0.71 CCR1 (0.52) MAPTLMNASMN1; SMN2ALDH1A1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1531822-A1 1-ARYL-4-SUBSTITUTED PIPERAZINE DERIVATIVES FOR USE AS CCR1 ANTAGONISTS FOR THE TREATMENT OF INFLAMMATION AND IMMUNE DISORDERS Chemocentryx, Inc. (US) 2005-05-25 EP disclosed
WO-2003105853-A1 1-ARYL-4-SUBSTITUTED PIPERAZINES DERIVATIVES FOR USE AS CCR1 ANTAGONISTS FOR THE TREATMENT OF INFLAMMATION AND IMMUNE DISORDERS CHEMOCENTRYX, INC. (US) 2003-12-24 WO disclosed