SCHEMBL6169411

SCHEMBL6169411

CC(=O)C(=Cc1ccc(Cl)cc1)c1ccccc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.55
HTT P42858 3/20 0.55
AKR1C1 Q04828 7/20 0.55
AKR1C2 P52895 6/20 0.55
AKR1C3 P42330 5/20 0.55
MAOB P27338 1/20 0.51
PTGS2 P35354 2/20 0.50
CYP2C9 P11712 2/20 0.50
MEN1 O00255 3/20 0.49
MAPT P10636 3/20 0.49
KMT2A Q03164 3/20 0.49
NPSR1 Q6W5P4 2/20 0.49
LMNA P02545 2/20 0.49
SMN1; SMN2 Q16637 2/20 0.49
NPC1 O15118 1/20 0.49
CYP1A2 P05177 1/20 0.49
CYP3A4 P08684 1/20 0.49
CYP2C19 P33261 1/20 0.49
RAB9A P51151 1/20 0.49
GLA P06280 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6169410 1.00 ALDH1A1 (0.55) ALDH1A1HTTAKR1C1AKR1C2AKR1C3
SCHEMBL11079768 0.93 HTT (0.55) ALDH1A1HTTAKR1C1AKR1C2AKR1C3
SCHEMBL11079773 0.93 HTT (0.55) ALDH1A1HTTAKR1C1AKR1C2AKR1C3
SCHEMBL5183481 0.87 AKR1C1 (0.70) ALDH1A1HTTAKR1C1AKR1C2AKR1C3
SCHEMBL7992874 0.87 AKR1C1 (0.70) ALDH1A1HTTAKR1C1AKR1C2AKR1C3
SCHEMBL6172379 0.87 AKR1C1 (0.70) ALDH1A1HTTAKR1C1AKR1C2AKR1C3
SCHEMBL7814857 0.86 AKR1C1 (0.75) ALDH1A1HTTAKR1C1AKR1C2AKR1C3
SCHEMBL11328602 0.86 AKR1C1 (0.75) ALDH1A1HTTAKR1C1AKR1C2AKR1C3
SCHEMBL28584154 0.86 ALDH1A1 (0.58) ALDH1A1HTTAKR1C1AKR1C2AKR1C3
SCHEMBL6168722 0.84 AKR1C1 (0.56) ALDH1A1HTTAKR1C1AKR1C2AKR1C3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3571183-B1 3-(PHENYL)-2-(AMINOMETHYL)-1-PHENYL-2-PROPEN-1-ONE DERIVATIVES AS INHIBITORS OF THE N-TERMINAL DOMAIN OF THE ANDROGEN RECEPTOR FOR TREATING PROSTATE CANCER UNIV CALIFORNIA (US) 2024-03-06 EP disclosed
EP-1528059-A2 Substituted isoxazoles for the treatment of inflammation G.D. Searle LLC (US) 2005-05-04 EP disclosed
EP-0809636-B1 SUBSTITUTED ISOXAZOLES FOR THE TREATMENT OF INFLAMMATION SEARLE & CO (US) 2002-09-04 EP disclosed
EP-1223167-A2 Substituted isoxazoles for the treatment of inflammation G.D. Searle & Co. (US) 2002-07-17 EP disclosed
US-5859257-A ANTIINFLAMMATORY, ANTIARTHRITIC AGENTS G. D. SEARLE & CO. (US) 1999-01-12 US disclosed
EP-0809636-A1 SUBSTITUTED ISOXAZOLES FOR THE TREATMENT OF INFLAMMATION G.D. SEARLE & CO. (US) 1997-12-03 EP disclosed
WO-1996025405-A1 SUBSTITUTED ISOXAZOLES FOR THE TREATMENT OF INFLAMMATION G.D. SEARLE & CO. (US) 1996-08-22 WO disclosed