Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 4/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.39 |
| ▸ | PDE1A | P54750 | 1/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.39 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 4/20 | 0.37 |
| ▸ | JAK1 | P23458 | 3/20 | 0.37 |
| ▸ | TYK2 | P29597 | 2/20 | 0.37 |
| ▸ | JAK3 | P52333 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | NEK2 | P51955 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6166854 | 0.91 | HCRTR1 (0.36) | HCRTR1HCRTR2PDE1APDE1BPDE1C | |
| SCHEMBL6167070 | 0.91 | HCRTR1 (0.38) | HCRTR1HCRTR2ABCB1KDM4EHSD17B10 | |
| Ethylene SCHEMBL4115800 | 0.83 | HCRTR1 (0.44) | HCRTR1HCRTR2JAK2JAK1TYK2 | |
| SCHEMBL4117342 | 0.82 | HCRTR1 (0.45) | HCRTR1HCRTR2JAK2JAK1TYK2 | |
| SCHEMBL4763764 | 0.74 | TGFBR1 (0.49) | JAK2JAK1TYK2JAK3KDM4E | |
| Ethylene SCHEMBL4111191 | 0.74 | HCRTR1 (0.41) | HCRTR1HCRTR2JAK2JAK1TYK2 | |
| SCHEMBL4122785 | 0.74 | HCRTR1 (0.42) | HCRTR1HCRTR2JAK2JAK1TYK2 | |
| SCHEMBL4109868 | 0.74 | FYN (0.50) | — | |
| Ethylene SCHEMBL4120382 | 0.73 | PDE4D (0.43) | HCRTR1HCRTR2KDM4E | |
| SCHEMBL4122248 | 0.73 | PDE4D (0.45) | HCRTR1HCRTR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1494670-A1 | MEDICINE FOR TREATING CANCER | Kowa Co., Ltd. (JP) | 2005-01-12 | — | — | EP | disclosed |
| WO-2003086397-A1 | MEDICINE FOR TREATING CANCER | KOWA CO., LTD. (JP) | 2003-10-23 | — | — | WO | disclosed |