SCHEMBL6169725

SCHEMBL6169725

CC(=O)Nc1ccc(C(=O)Nc2ccc3ccn(C(=O)OC(C)(C)C)c3c2)c(NC(=O)C2CCN(c3ccncc3)CC2)c1

nearest known ligand 0.45

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
F10 P00742 16/20 0.39
MAPT P10636 1/20 0.39
RXFP1 Q9HBX9 1/20 0.39
F2 P00734 2/20 0.38
ELANE P08246 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6171248 0.92 F10 (0.43) F10F2ELANE
SCHEMBL6170090 0.91 F10 (0.41) F10F2ELANE
SCHEMBL7082624 0.91 F10 (0.45) F10RXFP1F2ELANE
SCHEMBL6171175 0.89 F10 (0.46) F10MAPTRXFP1
SCHEMBL6168512 0.87 F10 (0.45) F10F2ELANE
SCHEMBL6168757 0.85 F10 (0.43) F10F2ELANE
SCHEMBL6169760 0.85 F10 (0.48) F10MAPTRXFP1F2ELANE
SCHEMBL7372221 0.83 F10 (0.39) F10RXFP1F2ELANE
SCHEMBL6169049 0.81 F10 (0.38) F10
SCHEMBL6168830 0.81 F10 (0.36) F10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1019045-B1 ANTITHROMBOTIC AGENTS LILLY CO ELI (US) 2005-06-08 EP disclosed
US-20030078431-A1 Antithrombotic agents BEIGHT DOUGLAS WADE (US) 2003-04-24 US disclosed
US-6500851-B2 ANTICOAGULANT IN MAMMLS ELI LILLY AND COMPANY 2002-12-31 US disclosed
US-20020173518-A1 Antithrombotic agents BEIGHT DOUGLAS WADE (US) 2002-11-21 US disclosed
US-6372759-B1 BLOOD COAGULATION FACTOR XA FOR MAMMALS ELI LILLY AND COMPANY 2002-04-16 US disclosed
WO-1999000128-A9 ANTITHROMBOTIC AGENTS LILLY CO ELI (US) 1999-08-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020173518-A1 Antithrombotic agents SERPINC1, TFPI, F11 F10 15/4885MAPT 4730/4885RXFP1 595/4885
US-20030078431-A1 Antithrombotic agents SERPINC1, TFPI, F11 F10 15/4885MAPT 4730/4885RXFP1 595/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.