Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.60 |
| ▸ | ACE | P12821 | 3/20 | 0.57 |
| ▸ | CTSS | P25774 | 5/20 | 0.56 |
| ▸ | CTSK | P43235 | 4/20 | 0.56 |
| ▸ | PPARA | Q07869 | 5/20 | 0.52 |
| ▸ | PPARG | P37231 | 4/20 | 0.52 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.52 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.52 |
| ▸ | CTSB | P07858 | 2/20 | 0.51 |
| ▸ | CTSL | P07711 | 1/20 | 0.51 |
| ▸ | ITGA4 | P13612 | 3/20 | 0.50 |
| ▸ | ITGB7 | P26010 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | PPARD | Q03181 | 1/20 | 0.50 |
| ▸ | MME | P08473 | 1/20 | 0.50 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.50 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1823733 | 0.90 | CTSS (0.53) | PTPN1ACECTSSCTSKPPARA | |
| SCHEMBL8485076 | 0.89 | CTSS (0.57) | PTPN1ACECTSSCTSKPPARA | |
| SCHEMBL1326276 | 0.86 | CTSS (0.72) | PTPN1ACECTSSCTSKPPARA | |
| SCHEMBL1325181 | 0.86 | CTSS (0.72) | PTPN1ACECTSSCTSKPPARA | |
| SCHEMBL1325182 | 0.86 | CTSS (0.72) | PTPN1ACECTSSCTSKPPARA | |
| SCHEMBL23001196 | 0.86 | PTPN1 (0.53) | PTPN1ACECTSSCTSKPPARA | |
| SCHEMBL13227703 | 0.85 | PTPN1 (0.63) | PTPN1ACECTSSCTSKPPARA | |
| SCHEMBL3728073 | 0.84 | PTPN1 (0.62) | PTPN1ACECTSSCTSKPPARA | |
| SCHEMBL3728076 | 0.84 | PTPN1 (0.62) | PTPN1ACECTSSCTSKPPARA | |
| SCHEMBL3724246 | 0.83 | ITGA4 (0.63) | PTPN1ACEITGA4ITGB7ITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888341-B1 | NOVEL SULPHUR DERIVATIVES COMPRISING AN AMIDE BOND, METHOD FOR PREPARING SAME, USE THEREOF AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH DERIVATIVES | AVENTIS PHARMA SA (FR) | 2005-11-30 | — | — | EP | disclosed |
| US-6136842-A | INHIBITION OF ENDOTHELIN-CONVERTING ENZYME | HOECHST MARION ROUSSEL (FR) | 2000-10-24 | — | — | US | disclosed |