Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.53 |
| ▸ | NPC1 | O15118 | 6/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PRNP | P04156 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6168162 | 0.82 | RXFP1 (0.40) | RAB9ASMN1; SMN2NPC1LMNATP53 | |
| SCHEMBL6170415 | 0.81 | USP2 (0.49) | RAB9ASMN1; SMN2NPC1L3MBTL1POLB | |
| SCHEMBL6169954 | 0.80 | HIF1A (0.45) | RAB9ANPC1LMNAHPGDALDH1A1 | |
| SCHEMBL3520666 | 0.79 | SMN1; SMN2 (0.53) | RAB9ASMN1; SMN2NPC1L3MBTL1POLB | |
| SCHEMBL6170192 | 0.77 | TRPV1 (0.46) | RAB9ANPC1MEN1KMT2AHTT | |
| SCHEMBL17454396 | 0.77 | ALDH1A1 (0.40) | RAB9ASMN1; SMN2L3MBTL1TP53ALDH1A1 | |
| SCHEMBL17437997 | 0.76 | MAPT (0.48) | RAB9AL3MBTL1POLBTP53HPGD | |
| SCHEMBL3635258 | 0.76 | ALDH1A1 (0.49) | SMN1; SMN2LMNAGAAALDH1A1MAPT | |
| SCHEMBL17438051 | 0.75 | PTPN1 (0.42) | SMN1; SMN2NPC1L3MBTL1POLBTP53 | |
| SCHEMBL6168967 | 0.73 | ALDH1A1 (0.43) | RAB9ASMN1; SMN2NPC1L3MBTL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1531812-A1 | FUSED HETEROARYL DERIVATIVES FOR USE AS P38 KINASE INHIBITORS IN THE TREATMENT OF I.A. RHEUMATOID ARTHRISTIS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004010995-A1 | FUSED HETEROARYL DERIVATIVES FOR USE AS P38 KINASE INHIBITORS IN THE TREATMENT OF I.A. RHEUMATOID ARTHRISTIS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-02-05 | — | — | WO | disclosed |