Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.39 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6169954 | 0.81 | HIF1A (0.45) | RAB9AKMT2AMEN1NPC1HIF1A | |
| SCHEMBL6168162 | 0.80 | RXFP1 (0.40) | RAB9AKMT2AMEN1NPC1HTT | |
| SCHEMBL5404456 | 0.80 | CHRNA7 (0.51) | — | |
| SCHEMBL3521624 | 0.78 | HIF1A (0.59) | TRPV1RAB9AKMT2AMEN1NPC1 | |
| SCHEMBL6169856 | 0.77 | RAB9A (0.53) | RAB9AKMT2AMEN1NPC1HTT | |
| SCHEMBL17438051 | 0.76 | PTPN1 (0.42) | KMT2AMEN1NPC1HTT | |
| SCHEMBL17454396 | 0.75 | ALDH1A1 (0.40) | RAB9AKMT2AMEN1HTT | |
| SCHEMBL14492288 | 0.75 | RAB9A (0.58) | RAB9AKMT2ANPC1HIF1A | |
| SCHEMBL14506769 | 0.75 | RAB9A (0.58) | RAB9AKMT2ANPC1HIF1A | |
| SCHEMBL17437997 | 0.74 | MAPT (0.48) | RAB9AKMT2AMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1531812-A1 | FUSED HETEROARYL DERIVATIVES FOR USE AS P38 KINASE INHIBITORS IN THE TREATMENT OF I.A. RHEUMATOID ARTHRISTIS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004010995-A1 | FUSED HETEROARYL DERIVATIVES FOR USE AS P38 KINASE INHIBITORS IN THE TREATMENT OF I.A. RHEUMATOID ARTHRISTIS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-02-05 | — | — | WO | disclosed |