SCHEMBL1408896

SCHEMBL1408896

COC(=O)c1c2c(c3ccccc3c1O)OC(c1ccc(OC)cc1)(c1ccc(OC)cc1)C=C2

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ATM Q13315 2/20 0.41
L3MBTL1 Q9Y468 2/20 0.41
TDP1 Q9NUW8 1/20 0.39
CA1 P00915 1/20 0.37
CA2 P00918 1/20 0.37
KDM4E B2RXH2 5/20 0.36
ALDH1A1 P00352 3/20 0.36
MAPT P10636 3/20 0.36
GAA P10253 2/20 0.36
HPGD P15428 2/20 0.36
POLB P06746 1/20 0.36
ALOX15 P16050 1/20 0.36
HTT P42858 4/20 0.36
NPSR1 Q6W5P4 1/20 0.36
PADI4 Q9UM07 1/20 0.36
MAPK1 P28482 3/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
TP53 P04637 1/20 0.34
THRB P10828 1/20 0.34
LMNA P02545 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29565080 1.00 ATM (0.41) ATML3MBTL1TDP1CA1CA2
SCHEMBL8978509 0.98 L3MBTL1 (0.40) ATML3MBTL1TDP1CA1CA2
SCHEMBL29565483 0.98 L3MBTL1 (0.40) ATML3MBTL1TDP1CA1CA2
SCHEMBL5644282 0.91 ALDH1A1 (0.39) L3MBTL1CA1CA2KDM4EALDH1A1
SCHEMBL5645434 0.90 L3MBTL1 (0.38) ATML3MBTL1TDP1CA1CA2
SCHEMBL29913570 0.90 KDM4E (0.36) ATML3MBTL1TDP1CA1CA2
SCHEMBL8978570 0.90 KDM4E (0.36) ATML3MBTL1TDP1CA1CA2
SCHEMBL6169861 0.89 ATM (0.41) ATML3MBTL1TDP1CA1CA2
SCHEMBL8978512 0.89 ATM (0.41) ATML3MBTL1TDP1CA1CA2
SCHEMBL6169985 0.88 L3MBTL1 (0.43) ATML3MBTL1TDP1CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 78 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12285922-B2 Method for making photofunctional contact lenses ALCON INC. (CH) 2025-04-29 US claimed
EP-4313567-B1 METHOD FOR MAKING PHOTOCHROMIC CONTACT LENSES ALCON INC (CH) 2025-01-29 EP claimed
US-11945895-B2 Photochromic polydiorganosiloxane vinylic crosslinkers ALCON INC. (CH) 2024-04-02 US claimed
CN-115605529-B Photochromic polydiorganosiloxane vinyl cross-linking agent 爱尔康公司 2024-03-26 CN claimed
EP-4118134-B1 PHOTOCHROMIC POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS ALCON INC (CH) 2024-02-28 EP claimed
EP-4304842-A1 METHOD FOR MAKING PHOTOFUNCTIONAL CONTACT LENSES Alcon Inc. (CH) 2024-01-17 EP claimed
US-11833771-B2 Method for making photochromic contact lenses ALCON INC. (CH) 2023-12-05 US claimed
EP-4118134-A1 PHOTOCHROMIC POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS Alcon Inc. (CH) 2023-01-18 EP claimed
CN-115605529-A Photochromic polydiorganosiloxane ethylene crosslinkers 爱尔康公司(CH) 2023-01-13 CN claimed
US-20220339895-A1 METHOD FOR MAKING PHOTOCHROMIC CONTACT LENSES ALCON INC. (CH) 2022-10-27 US claimed
US-20220281193-A1 METHOD FOR MAKING PHOTOFUNCTIONAL CONTACT LENSES ALCON INC. (CH) 2022-09-08 US claimed
WO-2021181307-A1 PHOTOCHROMIC POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS ALCON INC. (CH) 2021-09-16 WO claimed
WO-2021181341-A1 PHOTOCHROMIC POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS ALCON INC. (CH) 2021-09-16 WO claimed
US-20210284806-A1 PHOTOCHROMIC POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS ALCON INC. (CH) 2021-09-16 US claimed
US-20210284778-A1 PHOTOCHROMIC POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS ALCON INC (CH) 2021-09-16 US claimed
US-7166357-B2 Photochromic articles that activate behind ultraviolet radiation blocking transparencies and methods for preparation TRANSITIONS OPTICAL, INC. (US) 2007-01-23 US claimed
US-5458814-A Ophthalmic lenses TRANSITIONS OPTICAL, INC. (US) 1995-10-17 US claimed
WO-1995016215-A1 NOVEL SUBSTITUTED NAPHTHOPYRANS PPG INDUSTRIES, INC. (US) 1995-06-15 WO claimed
US-12285922-B2 Method for making photofunctional contact lenses ALCON INC. (CH) 2025-04-29 US disclosed
WO-1995016215-A1 NOVEL SUBSTITUTED NAPHTHOPYRANS PPG INDUSTRIES, INC. (US) 1995-06-15 WO disclosed