SCHEMBL6169879

SCHEMBL6169879

CC(C)NC(=O)CCc1ccc2ccccc2c1

nearest known ligand 0.68

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.60
HCAR2 Q8TDS4 1/20 0.55
HDAC1 Q13547 1/20 0.54
HDAC8 Q9BY41 1/20 0.54
CYP1A2 P05177 2/20 0.53
FFAR1 O14842 2/20 0.52
UTS2R Q9UKP6 3/20 0.51
CYP3A4 P08684 1/20 0.50
CYP2D6 P10635 1/20 0.50
CYP2C9 P11712 1/20 0.50
CYP2C19 P33261 1/20 0.50
HIF1A Q16665 1/20 0.50
KMT2A Q03164 1/20 0.49
PDPK1 O15530 1/20 0.49
CES2 O00748 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6172461 0.83 HDAC1 (0.57) HCAR2HDAC1HDAC8CYP1A2FFAR1
SCHEMBL12934918 0.82 ALDH1A1 (0.77) ALDH1A1HDAC1HDAC8FFAR1KMT2A
SCHEMBL21930778 0.82 ELANE (0.53) HCAR2HDAC1HDAC8CYP1A2UTS2R
SCHEMBL21930742 0.81 UTS2R (0.51) ALDH1A1HCAR2HDAC1HDAC8CYP1A2
SCHEMBL10362477 0.81 HDAC1 (0.77) HCAR2HDAC1HDAC8CYP1A2
SCHEMBL7772333 0.80 ALDH1A1 (0.66) ALDH1A1HDAC1HDAC8FFAR1
SCHEMBL21933749 0.80 HDAC1 (0.55) ALDH1A1HCAR2HDAC1HDAC8CYP1A2
SCHEMBL18269436 0.80 CYP1A2 (0.57) HCAR2HDAC1HDAC8CYP1A2FFAR1
SCHEMBL6169205 0.78 HPGD (0.63) HDAC1HDAC8CYP1A2
SCHEMBL9404005 0.77 CYP1A2 (0.62) HCAR2HDAC1HDAC8CYP1A2FFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1556361-A2 2-ALKYL-(2-AMINO-3-ARYL-PROPIONYL)-PIPERAZINE DERIVATIVES AND RELATED COMPOUNDS AS MELANOCORTIN RECEPTOR LIGANDS FOR THE TREATMENT OF OBESITY THE PROCTER & GAMBLE COMPANY (US) 2005-07-27 EP claimed
WO-2004037797-A2 2 - ALKYL - (2 - AMINO - 3 - ARYL - PROPIONYL) - PIPERAZINE DERIVATIVES AND RELATED COMPOUNDS AS MELANOCORTIN RECEPTOR LIGANDS FOR THE TREATMENT OF OBESITY THE PROCTER & GAMBLE COMPANY (US) 2004-05-06 WO claimed