Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | PADI4 | Q9UM07 | 3/20 | 0.37 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6931279 | 0.92 | SMN1; SMN2 (0.46) | L3MBTL1ATMTP53THRBSMN1; SMN2 | |
| SCHEMBL6131950 | 0.91 | L3MBTL1 (0.41) | L3MBTL1ATMTP53THRBSMN1; SMN2 | |
| SCHEMBL5107968 | 0.91 | MAPK8 (0.41) | L3MBTL1ATMTP53THRBSMN1; SMN2 | |
| SCHEMBL1332525 | 0.91 | ATM (0.40) | L3MBTL1ATMTP53THRBSMN1; SMN2 | |
| SCHEMBL29565863 | 0.91 | ATM (0.40) | L3MBTL1ATMTP53THRBSMN1; SMN2 | |
| SCHEMBL5107921 | 0.90 | L3MBTL1 (0.40) | L3MBTL1ATMTP53THRBSMN1; SMN2 | |
| SCHEMBL10102253 | 0.89 | SMN1; SMN2 (0.45) | L3MBTL1ATMTP53SMN1; SMN2TDP1 | |
| SCHEMBL8920456 | 0.89 | L3MBTL1 (0.39) | L3MBTL1ATMTP53THRBSMN1; SMN2 | |
| SCHEMBL29565468 | 0.89 | L3MBTL1 (0.39) | L3MBTL1ATMTP53THRBSMN1; SMN2 | |
| SCHEMBL6131971 | 0.89 | L3MBTL1 (0.41) | L3MBTL1ATMTDP1LMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1360183-B1 | NOVEL PHOTOCHROMIC INDENONAPHTHOPYRAN COMPOUNDS | TRANSITIONS OPTICAL INC (US) | 2005-08-17 | — | — | EP | disclosed |
| EP-1112263-B1 | POLYMERIZABLE POLYALKOXYLATED NAPHTHOPYRANS | TRANSITIONS OPTICAL INC (US) | 2005-06-08 | — | — | EP | disclosed |
| EP-0835870-B1 | Photochromic substituted naphthopyrans | PPG IND OHIO INC (US) | 2004-03-03 | — | — | EP | disclosed |
| US-6113814-A | PHOTOCHROMIC; END-CAPPED WITH A POLYMERIZABLE GROUP. | TRANSITIONS OPTICAL, INC. (US) | 2000-09-05 | — | — | US | disclosed |
| EP-0835870-A1 | Photochromic substituted naphthopyrans | PPG INDUSTRIES, INC. (US) | 1998-04-15 | — | — | EP | disclosed |
| US-5656206-A | OPHTHALIMIC LENSES; RADIATION TRANSPARENT; PHOTOCHROMISM | TRANSITIONS OPTICAL, INC. (US) | 1997-08-12 | — | — | US | disclosed |
| US-5645767-A | PLASTIC LENSES, WINDOWS, BATHOCHROMIC SHIFT FOR WAVELENGTHS IN VISIBLE SPECTRUM | TRANSITIONS OPTICAL, INC. (US) | 1997-07-08 | — | — | US | disclosed |
| WO-1996014596-A1 | NOVEL PHOTOCHROMIC INDENO-FUSED NAPHTHOPYRANS | PPG INDUSTRIES, INC. (US) | 1996-05-17 | — | — | WO | disclosed |