SCHEMBL6931279

SCHEMBL6931279

COC(=O)c1c2c(c3ccccc3c1-c1ccccc1)OC(c1ccccc1)(c1ccccc1)C=C2

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.46
LMNA P02545 4/20 0.41
ALDH1A1 P00352 3/20 0.38
RAB9A P51151 2/20 0.38
GPR84 Q9NQS5 1/20 0.38
MAPK8 P45983 1/20 0.37
PTGS1 P23219 1/20 0.37
TP53 P04637 2/20 0.37
AR P10275 1/20 0.37
PLA2G2A P14555 1/20 0.37
MAPK1 P28482 1/20 0.36
TSHR P16473 2/20 0.36
HTT P42858 1/20 0.35
IDO1 P14902 1/20 0.35
PTPN1 P18031 1/20 0.35
HPGD P15428 2/20 0.35
KDM4E B2RXH2 1/20 0.35
NPC1 O15118 1/20 0.35
HSD17B10 Q99714 1/20 0.35
MEN1 O00255 3/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10102253 0.94 SMN1; SMN2 (0.45) SMN1; SMN2LMNAALDH1A1RAB9AGPR84
SCHEMBL6169985 0.92 L3MBTL1 (0.43) SMN1; SMN2LMNAALDH1A1RAB9AGPR84
SCHEMBL5107968 0.90 MAPK8 (0.41) SMN1; SMN2LMNAALDH1A1MAPK8TP53
SCHEMBL7608091 0.88 SMN1; SMN2 (0.41) SMN1; SMN2LMNAALDH1A1RAB9AGPR84
SCHEMBL5644282 0.88 ALDH1A1 (0.39) SMN1; SMN2LMNAALDH1A1RAB9AGPR84
SCHEMBL7001887 0.87 EGFR (0.41) SMN1; SMN2LMNAALDH1A1GPR84PTGS1
SCHEMBL5643452 0.87 SMN1; SMN2 (0.38) SMN1; SMN2LMNAALDH1A1RAB9AGPR84
SCHEMBL5107921 0.86 L3MBTL1 (0.40) SMN1; SMN2LMNAALDH1A1GPR84MAPK8
SCHEMBL1333859 0.85 ALOX5 (0.37) SMN1; SMN2LMNAALDH1A1RAB9AGPR84
SCHEMBL30914184 0.85 ALOX5 (0.37) SMN1; SMN2LMNAALDH1A1RAB9AGPR84

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0906366-B1 NOVEL PHOTOCHROMIC INDENO-FUSED NAPHTHOPYRANS TRANSITIONS OPTICAL INC (US) 2003-12-03 EP disclosed
EP-1112264-B1 POLYALKOXYLATED NAPHTHOPYRANS TRANSITIONS OPTICAL INC (US) 2002-11-27 EP disclosed
EP-0906366-A4 NOVEL PHOTOCHROMIC INDENO-FUSED NAPHTHOPYRANS TRANSITIONS OPTICAL INC (US) 1999-12-29 EP disclosed
US-5961892-A PHOTOCHROMIC PPG INDUSTRIES OHIO, INC. (US) 1999-10-05 US disclosed
US-5955520-A 1H-INDENO(2,1-F)NAPHTHO(1,2-B)PYRANS HAVING ACTIVATED COLORS RANGING FROM ORANGE TO BLUE/GRAY, AN ACCEPTABLE FADE RATE, HIGH ACTIVATED COLORS RANGING FROM ORGANE TO BLUE/GRAY, AN ACCEPTABLE FAD RATE, HIGH ACTIVATED INTENSITY PPG INDUSTRIES, INC. (US) 1999-09-21 US disclosed
EP-0906366-A1 NOVEL PHOTOCHROMIC INDENO-FUSED NAPHTHOPYRANS TRANSITIONS OPTICAL, INC. (US) 1999-04-07 EP disclosed
WO-1997048762-A1 NOVEL PHOTOCHROMIC INDENO-FUSED NAPHTHOPYRANS TRANSITIONS OPTICAL, INC. (US) 1997-12-24 WO disclosed