Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 7/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6170104 | 0.84 | NPC1 (0.54) | SMN1; SMN2MAPTKDM4EPDE4DALDH1A1 | |
| SCHEMBL6177322 | 0.81 | CYP1A2 (0.42) | SMN1; SMN2MAPTKDM4EMEN1KMT2A | |
| SCHEMBL6177927 | 0.76 | HPGD (0.42) | SMN1; SMN2MAPTKDM4EALDH1A1NPC1 | |
| SCHEMBL6097890 | 0.75 | SMN1; SMN2 (0.55) | SMN1; SMN2MAPTKDM4ELMNATP53 | |
| SCHEMBL6099027 | 0.73 | SMN1; SMN2 (0.53) | SMN1; SMN2MAPTLMNATP53CRHR1 | |
| SCHEMBL6096532 | 0.73 | SMN1; SMN2 (0.56) | SMN1; SMN2KDM4ECRHR1ALDH1A1 | |
| SCHEMBL28834473 | 0.70 | MEN1 (0.43) | SMN1; SMN2MAPTKDM4ELMNAPDE4D | |
| SCHEMBL2753561 | 0.70 | ALDH1A1 (0.47) | SMN1; SMN2MAPTKDM4ELMNAPDE4A | |
| SCHEMBL6096679 | 0.68 | SMN1; SMN2 (0.47) | SMN1; SMN2CRHR1PDE4DPOLB | |
| SCHEMBL16872802 | 0.67 | SMN1; SMN2 (0.58) | SMN1; SMN2MAPTKDM4ELMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1495005-A1 | PYRAZOLE COMPOUNDS AS ANTI-INFLAMMATORY AND ANALGESIC AGENTS | Pfizer Japan Inc. (JP) | 2005-01-12 | — | — | EP | claimed |
| WO-2003087061-A1 | PYRAZOLE COMPOUNDS AS ANTI-INFLAMMATORY AND ANALGESIC AGENTS | PFIZER JAPAN INC. (JP) | 2003-10-23 | — | — | WO | claimed |
| EP-1495005-A1 | PYRAZOLE COMPOUNDS AS ANTI-INFLAMMATORY AND ANALGESIC AGENTS | Pfizer Japan Inc. (JP) | 2005-01-12 | — | — | EP | disclosed |
| WO-2003087061-A1 | PYRAZOLE COMPOUNDS AS ANTI-INFLAMMATORY AND ANALGESIC AGENTS | PFIZER JAPAN INC. (JP) | 2003-10-23 | — | — | WO | disclosed |