Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 1/20 | 0.61 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.51 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | ELANE | P08246 | 3/20 | 0.48 |
| ▸ | PRTN3 | P24158 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1403296 | 1.00 | SNCA (0.61) | SNCAKEAP1NFE2L2CYP2C9CYP2C19 | |
| SCHEMBL18069272 | 0.87 | MEN1 (0.50) | SNCACYP2C9CYP2C19KMT2AALDH1A1 | |
| SCHEMBL6170396 | 0.86 | METAP2 (0.57) | SNCAKEAP1NFE2L2CYP2C9CYP2C19 | |
| SCHEMBL6169289 | 0.86 | METAP2 (0.54) | SNCAKEAP1NFE2L2CYP2C9CYP2C19 | |
| SCHEMBL6169064 | 0.86 | KEAP1 (0.49) | SNCAKEAP1NFE2L2KMT2AALDH1A1 | |
| SCHEMBL6169068 | 0.86 | KEAP1 (0.49) | SNCAKEAP1NFE2L2KMT2AALDH1A1 | |
| SCHEMBL6169283 | 0.86 | METAP2 (0.54) | SNCAKEAP1NFE2L2CYP2C9CYP2C19 | |
| SCHEMBL6170402 | 0.86 | METAP2 (0.57) | SNCAKEAP1NFE2L2CYP2C9CYP2C19 | |
| SCHEMBL8120283 | 0.85 | SNCA (0.56) | SNCAKEAP1NFE2L2CYP2C9CYP2C19 | |
| SCHEMBL8120286 | 0.85 | SNCA (0.56) | SNCAKEAP1NFE2L2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045833-B1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| US-6608070-B1 | Useful for treatment of medical condition in which prostaglandins are implicated as pathogens | NAKAO KAZUNARI (JP) | 2003-08-19 | — | — | US | disclosed |