Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.50 |
| ▸ | KIF11 | P52732 | 6/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6171485 | 0.92 | PTGS2 (0.56) | PTGS2PTGS1KIF11SORT1 | |
| SCHEMBL6172104 | 0.88 | PTGS2 (0.53) | PTGS2PTGS1 | |
| SCHEMBL6181624 | 0.87 | PTGS2 (0.66) | PTGS2PTGS1KIF11 | |
| SCHEMBL6171838 | 0.83 | PTGS2 (0.67) | PTGS2PTGS1KIF11 | |
| SCHEMBL6171712 | 0.83 | PTGS2 (0.68) | PTGS2PTGS1KIF11 | |
| SCHEMBL6171969 | 0.83 | PTGS2 (0.67) | PTGS2PTGS1MAPT | |
| SCHEMBL6170712 | 0.82 | PTGS2 (0.53) | PTGS2PTGS1MAPT | |
| SCHEMBL6171600 | 0.81 | PTGS2 (0.58) | PTGS2PTGS1MAPTSORT1 | |
| SCHEMBL6169979 | 0.81 | PTGS2 (0.76) | PTGS2PTGS1 | |
| SCHEMBL6173175 | 0.81 | PTGS2 (0.69) | PTGS2PTGS1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045833-B1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2005-11-02 | — | — | EP | claimed |
| US-6608070-B1 | Useful for treatment of medical condition in which prostaglandins are implicated as pathogens | NAKAO KAZUNARI (JP) | 2003-08-19 | — | — | US | claimed |
| US-6608070-B1 | Useful for treatment of medical condition in which prostaglandins are implicated as pathogens | NAKAO KAZUNARI (JP) | 2003-08-19 | — | — | US | disclosed |