Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 11/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6172560 | 0.91 | PTGS2 (0.50) | PTGS2PTGS1KDM4EGAA | |
| SCHEMBL6169271 | 0.91 | PTGS2 (0.66) | PTGS2PTGS1GABRA1GABRG2GABRB3 | |
| SCHEMBL6172104 | 0.91 | PTGS2 (0.53) | PTGS2PTGS1 | |
| SCHEMBL6174674 | 0.89 | PTGS2 (0.68) | PTGS2PTGS1KDM4EALDH1A1MEN1 | |
| SCHEMBL6171838 | 0.89 | PTGS2 (0.67) | PTGS2PTGS1GABRA1GABRG2GABRB3 | |
| SCHEMBL7202770 | 0.89 | PTGS2 (0.48) | PTGS2PTGS1KDM4EALDH1A1MEN1 | |
| SCHEMBL6168891 | 0.89 | PTGS2 (0.67) | PTGS2PTGS1KDM4EALDH1A1MEN1 | |
| SCHEMBL6171485 | 0.88 | PTGS2 (0.56) | PTGS2PTGS1MEN1KMT2A | |
| SCHEMBL6171600 | 0.88 | PTGS2 (0.58) | PTGS2PTGS1MEN1KMT2AMAPT | |
| SCHEMBL6171784 | 0.86 | PTGS2 (0.69) | PTGS2PTGS1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045833-B1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2005-11-02 | — | — | EP | claimed |
| US-6608070-B1 | Useful for treatment of medical condition in which prostaglandins are implicated as pathogens | NAKAO KAZUNARI (JP) | 2003-08-19 | — | — | US | claimed |
| US-6608070-B1 | Useful for treatment of medical condition in which prostaglandins are implicated as pathogens | NAKAO KAZUNARI (JP) | 2003-08-19 | — | — | US | disclosed |