Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | FKBP1A | P62942 | 7/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1646187 | 0.72 | CA1 (0.48) | CA1CA2POLBKMT2ATSHR | |
| SCHEMBL5224904 | 0.72 | CA1 (0.36) | CA1CA2POLBKMT2ATSHR | |
| SCHEMBL27994172 | 0.72 | CA1 (0.55) | CA1CA2POLBKMT2ATSHR | |
| SCHEMBL5181697 | 0.72 | CA1 (0.48) | CA1CA2POLBKMT2ATSHR | |
| SCHEMBL7024977 | 0.72 | CA1 (0.36) | CA1CA2POLBKMT2ATSHR | |
| SCHEMBL176589 | 0.72 | CA2 (0.36) | CA1CA2POLBKMT2ATSHR | |
| SCHEMBL17996182 | 0.71 | FKBP1A (0.43) | CA1CA2POLBKMT2ATSHR | |
| Hydrochloric Acid SCHEMBL11534985 | 0.70 | CA1 (0.35) | CA1CA2POLBKMT2ATSHR | |
| SCHEMBL2591313 | 0.70 | CA12 (0.38) | CA1CA2POLBKMT2ATSHR | |
| SCHEMBL27318690 | 0.70 | CA1 (0.35) | CA1CA2POLBKMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1527051-A1 | PYRIMIDYL SULPHONE AMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | Astrazeneca AB (SE) | 2005-05-04 | — | — | EP | disclosed |
| WO-2004011443-A1 | PYRIMIDYL SULPHONE AMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | disclosed |