Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 14/20 | 0.73 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.64 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.56 |
| ▸ | HTR3B | O95264 | 1/20 | 0.56 |
| ▸ | HTR3A | P46098 | 1/20 | 0.56 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.56 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.56 |
| ▸ | AAK1 | Q2M2I8 | 5/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13219734 | 0.83 | IMPDH2 (0.63) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL5524971 | 0.82 | IMPDH2 (0.67) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL5524963 | 0.82 | IMPDH2 (0.67) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL5531753 | 0.81 | IMPDH2 (0.66) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL5531750 | 0.81 | IMPDH2 (0.66) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL6171745 | 0.81 | IMPDH2 (0.66) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL4702533 | 0.80 | IMPDH2 (0.59) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL6639753 | 0.79 | IMPDH2 (1.00) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL1353846 | 0.79 | IMPDH2 (1.00) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL30298739 | 0.79 | IMPDH2 (1.00) | IMPDH2IMPDH1AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1126843-A4 | COMPOUNDS DERIVED FROM AN AMINE NUCLEUS THAT ARE INHIBITORS OF IMPDH ENZYME | BRISTOL MYERS SQUIBB CO (US) | 2005-06-15 | — | — | EP | disclosed |
| US-6399773-B1 | AUTOIMMUNE DISEASE; TRANSPLANTING ORGANS | BRISTOL-MYERS SQUIBB CO. | 2002-06-04 | — | — | US | disclosed |
| EP-1126843-A1 | COMPOUNDS DERIVED FROM AN AMINE NUCLEUS THAT ARE INHIBITORS OF IMPDH ENZYME | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-08-29 | — | — | EP | disclosed |
| WO-2000025780-A1 | COMPOUNDS DERIVED FROM AN AMINE NUCLEUS THAT ARE INHIBITORS OF IMPDH ENZYME | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-05-11 | — | — | WO | disclosed |