Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ARG1 | P05089 | 1/20 | 0.37 |
| ▸ | ARG2 | P78540 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17395338 | 1.00 | ARG1 (0.37) | ARG1ARG2CYP2C19SLC6A2SLC6A4 | |
| SCHEMBL2334849 | 0.95 | CYP2C19 (0.36) | ARG1ARG2CYP2C19 | |
| SCHEMBL17395342 | 0.94 | CYP2C19 (0.39) | ARG1ARG2CYP2C19 | |
| SCHEMBL17395386 | 0.92 | CYP2C19 (0.32) | CYP2C19 | |
| SCHEMBL5730696 | 0.79 | CTSK (0.34) | ARG1ARG2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7978321 | 0.78 | — | — | |
| SCHEMBL8116636 | 0.78 | ARG1 (0.40) | ARG1ARG2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL31603414 | 0.76 | NPSR1 (0.33) | ARG1ARG2CYP2C19 | |
| SCHEMBL4334068 | 0.76 | CYP2C19 (0.39) | CYP2C19SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5442859 | 0.76 | ARG1 (0.53) | ARG1ARG2CYP2C19SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016003296-A1 | (QUINOLINE OR ISOQUINOLINE)SULFONAMIDES OF CYCLIC AMINES AS ANTIPSYCHOTIC DRUGS | INSTYTUT FARMAKOLOGII POLSKIEJ AKADEMII NAUK (PL) | 2016-01-07 | — | — | WO | disclosed |
| EP-1549613-A1 | SULFONAMIDES HAVING ANTIANGIOGENIC AND ANTICANCER ACTIVITY | Abbott Laboratories (US) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004033419-A1 | SULFONAMIDES HAVING ANTIANGIOGENIC AND ANTICANCER ACTIVITY | ABBOTT LABORATORIES (US) | 2004-04-22 | — | — | WO | disclosed |