Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 14/20 | 0.56 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.56 |
| ▸ | MT-CO2 | P00403 | 3/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CA3 | P07451 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | CA6 | P23280 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4885453 | 0.86 | PTGS2 (0.69) | PTGS2NR4A2MT-CO2PTGS1CA12 | |
| SCHEMBL5073588 | 0.79 | PTGS2 (0.81) | PTGS2NR4A2MT-CO2PTGS1CA12 | |
| SCHEMBL8478348 | 0.78 | ALDH1A1 (0.45) | PTGS2NR4A2MT-CO2ALDH1A1PKM | |
| SCHEMBL5069853 | 0.76 | PTGS2 (0.67) | PTGS2NR4A2MT-CO2PTGS1CA12 | |
| SCHEMBL14340629 | 0.75 | PTGS2 (0.78) | PTGS2NR4A2MT-CO2PTGS1CA12 | |
| SCHEMBL5069870 | 0.74 | PTGS2 (0.77) | PTGS2NR4A2MT-CO2PTGS1CA12 | |
| SCHEMBL8478699 | 0.74 | PTGS2 (0.47) | PTGS2MT-CO2PTGS1CA12CA1 | |
| SCHEMBL4881634 | 0.73 | PTGS2 (0.77) | PTGS2MT-CO2PTGS1CA12CA1 | |
| SCHEMBL6170017 | 0.73 | PTGS2 (0.63) | PTGS2MT-CO2PTGS1PDE3A | |
| SCHEMBL5698463 | 0.73 | PTGS2 (0.63) | PTGS2MT-CO2PTGS1PDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1528059-A2 | Substituted isoxazoles for the treatment of inflammation | G.D. Searle LLC (US) | 2005-05-04 | — | — | EP | disclosed |
| EP-0809636-B1 | SUBSTITUTED ISOXAZOLES FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2002-09-04 | — | — | EP | disclosed |
| EP-1223167-A2 | Substituted isoxazoles for the treatment of inflammation | G.D. Searle & Co. (US) | 2002-07-17 | — | — | EP | disclosed |