Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 1/20 | 0.60 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.60 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.60 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.52 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.52 |
| ▸ | CCR2 | P41597 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.48 |
| ▸ | ACLY | P53396 | 1/20 | 0.48 |
| ▸ | CPT1A | P50416 | 1/20 | 0.47 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.47 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.45 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.45 |
| ▸ | ITGAL | P20701 | 1/20 | 0.45 |
| ▸ | METAP2 | P50579 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6170634 | 1.00 | ERBB2 (0.60) | ERBB2HSP90AA1HSP90AB1KEAP1NFE2L2 | |
| SCHEMBL6172083 | 0.90 | ERBB2 (0.57) | ERBB2HSP90AA1HSP90AB1KEAP1NFE2L2 | |
| SCHEMBL6172085 | 0.90 | ERBB2 (0.57) | ERBB2HSP90AA1HSP90AB1KEAP1NFE2L2 | |
| SCHEMBL6170544 | 0.88 | ERBB2 (0.55) | ERBB2HSP90AA1HSP90AB1KEAP1NFE2L2 | |
| SCHEMBL6170538 | 0.88 | ERBB2 (0.55) | ERBB2HSP90AA1HSP90AB1KEAP1NFE2L2 | |
| SCHEMBL7488011 | 0.85 | KEAP1 (0.53) | ERBB2HSP90AA1HSP90AB1KEAP1NFE2L2 | |
| SCHEMBL7488003 | 0.85 | KEAP1 (0.53) | ERBB2HSP90AA1HSP90AB1KEAP1NFE2L2 | |
| SCHEMBL8120283 | 0.83 | SNCA (0.56) | KEAP1NFE2L2HTT | |
| SCHEMBL8120286 | 0.83 | SNCA (0.56) | KEAP1NFE2L2HTT | |
| SCHEMBL8112835 | 0.82 | MEN1 (0.48) | ERBB2HSP90AA1HSP90AB1KEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045833-B1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| US-6608070-B1 | Useful for treatment of medical condition in which prostaglandins are implicated as pathogens | NAKAO KAZUNARI (JP) | 2003-08-19 | — | — | US | disclosed |
| EP-1065206-B1 | Tetrazolylalkyl indole compounds as anti-inflammatory and analgesic agents | PFIZER (US) | 2002-10-09 | — | — | EP | disclosed |
| EP-1065206-A1 | Tetrazolylalkyl indole compounds as anti-inflammatory and analgesic agents | PFIZER INC. (US) | 2001-01-03 | — | — | EP | disclosed |
| EP-1045833-A1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER INC. (US) | 2000-10-25 | — | — | EP | disclosed |
| WO-1999035130-A1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 1999-07-15 | — | — | WO | disclosed |