Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 2/20 | 0.53 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | METAP2 | P50579 | 3/20 | 0.47 |
| ▸ | IKBKB | O14920 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7488003 | 1.00 | KEAP1 (0.53) | KEAP1NFE2L2USP2TDP1NPSR1 | |
| SCHEMBL7487670 | 0.91 | KEAP1 (0.52) | KEAP1NFE2L2USP2TDP1NPSR1 | |
| SCHEMBL7487663 | 0.91 | KEAP1 (0.52) | KEAP1NFE2L2USP2TDP1NPSR1 | |
| SCHEMBL6169064 | 0.87 | KEAP1 (0.49) | KEAP1NFE2L2NPSR1METAP2ALDH1A1 | |
| SCHEMBL6169068 | 0.87 | KEAP1 (0.49) | KEAP1NFE2L2NPSR1METAP2ALDH1A1 | |
| SCHEMBL6170634 | 0.85 | ERBB2 (0.60) | KEAP1NFE2L2METAP2HTTERBB2 | |
| SCHEMBL6170638 | 0.85 | ERBB2 (0.60) | KEAP1NFE2L2METAP2HTTERBB2 | |
| SCHEMBL7486563 | 0.85 | KDM1A (0.52) | KEAP1NFE2L2ALDH1A1GAA | |
| SCHEMBL7486570 | 0.85 | KDM1A (0.52) | KEAP1NFE2L2ALDH1A1GAA | |
| SCHEMBL8120283 | 0.84 | SNCA (0.56) | KEAP1NFE2L2USP2TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1065206-B1 | Tetrazolylalkyl indole compounds as anti-inflammatory and analgesic agents | PFIZER (US) | 2002-10-09 | — | — | EP | disclosed |
| EP-1065206-A1 | Tetrazolylalkyl indole compounds as anti-inflammatory and analgesic agents | PFIZER INC. (US) | 2001-01-03 | — | — | EP | disclosed |