Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 5/20 | 0.55 |
| ▸ | ENPP3 | O14638 | 3/20 | 0.51 |
| ▸ | ENPP1 | P22413 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 7/20 | 0.45 |
| ▸ | NPC1 | O15118 | 6/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | DHPS | P49366 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5836665 | 0.89 | ENPP3 (0.61) | MMP13ENPP3ENPP1RAB9ANPC1 | |
| SCHEMBL6170726 | 0.86 | MMP13 (0.50) | MMP13ENPP3ENPP1RAB9ANPC1 | |
| SCHEMBL6170686 | 0.85 | MAPT (0.47) | MMP13ENPP3ENPP1RAB9ANPC1 | |
| SCHEMBL5836726 | 0.81 | MMP13 (0.55) | MMP13ENPP3ENPP1RAB9ANPC1 | |
| SCHEMBL6170731 | 0.77 | MMP13 (0.44) | MMP13ENPP3ENPP1RAB9ANPC1 | |
| SCHEMBL5836663 | 0.77 | MMP13 (0.50) | MMP13ENPP3ENPP1RAB9ANPC1 | |
| SCHEMBL5835666 | 0.71 | MMP13 (1.00) | MMP13 | |
| SCHEMBL5836271 | 0.71 | ENPP3 (0.89) | MMP13ENPP3ENPP1RAB9ANPC1 | |
| SCHEMBL5836404 | 0.71 | MMP13 (0.62) | MMP13ENPP3ENPP1RAB9ANPC1 | |
| SCHEMBL8399604 | 0.68 | ENPP3 (0.84) | ENPP3ENPP1RAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501515-A1 | TRIARYL-OXY-ARYLOXY-PYRIMIDINE-2,4,6-TRIONE METALLOPROTEINASE INHIBITORS | Pfizer Products Inc. (US) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003090752-A1 | TRIARYL-OXY-ARYLOXY-PYRIMIDINE-2,4,6-TRIONE METALLOPROTEINASE INHIBITORS | PFIZER PRODUCTS INC. (US) | 2003-11-06 | — | — | WO | disclosed |