SCHEMBL6170843

SCHEMBL6170843

CS(=O)(=O)c1ccc(-c2cc(C(F)(F)F)cnc2N2CCC[C@@H]2CO)cc1

nearest known ligand 0.70

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 12/20 0.70
PTGS1 P23219 6/20 0.70
GCK P35557 1/20 0.46
PTGDR2 Q9Y5Y4 1/20 0.45
IDO1 P14902 1/20 0.44
GPR119 Q8TDV5 1/20 0.42
CCNE2 O96020 1/20 0.41
CDK4 P11802 1/20 0.41
CCND1 P24385 1/20 0.41
CCNE1 P24864 1/20 0.41
CDK2 P24941 1/20 0.41
BRD4 O60885 1/20 0.41
BRD2 P25440 1/20 0.41
TACR1 P25103 2/20 0.40
TACR3 P29371 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6171370 1.00 PTGS2 (0.70) PTGS2PTGS1GCKPTGDR2IDO1
SCHEMBL6171626 0.97 PTGS2 (0.67) PTGS2PTGS1GCKPTGDR2IDO1
SCHEMBL6170845 0.91 PTGS2 (0.59) PTGS2PTGS1CCNE2CDK4CCND1
SCHEMBL6169810 0.90 PTGS2 (0.65) PTGS2PTGS1GCKPTGDR2IDO1
SCHEMBL6170522 0.90 PTGS2 (0.62) PTGS2PTGS1GCKPTGDR2IDO1
SCHEMBL6170449 0.88 PTGS2 (0.63) PTGS2PTGS1GCKPTGDR2IDO1
SCHEMBL6169356 0.88 PTGS2 (0.56) PTGS2PTGS1CCNE2CDK4CCND1
SCHEMBL6172213 0.85 PTGS2 (0.51) PTGS2PTGS1GPR119
SCHEMBL6169353 0.83 PTGS2 (1.00) PTGS2PTGS1GCK
SCHEMBL6172953 0.81 PTGS2 (0.52) PTGS2PTGS1GCK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1015431-B1 2-AMINOPYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2 MERCK FROSST CANADA INC (CA) 2005-04-20 EP claimed
EP-1015431-A1 2-AMINOPYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2 Merck Frosst Canada & Co. (CA) 2000-07-05 EP claimed
WO-1999014195-A1 2-AMINOPYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2 MERCK FROSST CANADA & CO. (CA) 1999-03-25 WO claimed
EP-1015431-B1 2-AMINOPYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2 MERCK FROSST CANADA INC (CA) 2005-04-20 EP disclosed
EP-1015431-A1 2-AMINOPYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2 Merck Frosst Canada & Co. (CA) 2000-07-05 EP disclosed
US-6004950-A NON-STEROIDAL ANTIINFLAMMATORY AGENTS; ANALGESIC, ANTIPYRETICS; SIDE EFFECT REDUCTION MERCK FROSST CANADA, INC. (CA) 1999-12-21 US disclosed
WO-1999014195-A1 2-AMINOPYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2 MERCK FROSST CANADA & CO. (CA) 1999-03-25 WO disclosed