SCHEMBL6170845

SCHEMBL6170845

CS(=O)(=O)c1cccc(-c2cc(C(F)(F)F)cnc2N2CCCC2CO)c1

nearest known ligand 0.59

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 9/20 0.59
PTGS1 P23219 6/20 0.59
IRAK4 Q9NWZ3 1/20 0.43
CCNE2 O96020 1/20 0.41
CDK4 P11802 1/20 0.41
CCND1 P24385 1/20 0.41
CCNE1 P24864 1/20 0.41
CDK2 P24941 1/20 0.41
TACR1 P25103 2/20 0.40
TACR3 P29371 2/20 0.40
NR1H2 P55055 2/20 0.40
NR1H3 Q13133 2/20 0.40
AOC3 Q16853 2/20 0.39
NTRK1 P04629 1/20 0.39
SPHK1 Q9NYA1 1/20 0.39
MEN1 O00255 1/20 0.39
ALDH1A1 P00352 1/20 0.39
KMT2A Q03164 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6169356 0.97 PTGS2 (0.56) PTGS2PTGS1IRAK4CCNE2CDK4
SCHEMBL6170843 0.91 PTGS2 (0.70) PTGS2PTGS1CCNE2CDK4CCND1
SCHEMBL6171370 0.91 PTGS2 (0.70) PTGS2PTGS1CCNE2CDK4CCND1
SCHEMBL6172953 0.90 PTGS2 (0.52) PTGS2PTGS1NR1H2NR1H3
SCHEMBL6171203 0.89 PTGS2 (0.53) PTGS2PTGS1NR1H2NR1H3
SCHEMBL6170450 0.88 PTGS2 (0.52) PTGS2PTGS1NR1H2NR1H3ALDH1A1
SCHEMBL6171626 0.88 PTGS2 (0.67) PTGS2PTGS1TACR1TACR3
SCHEMBL6172216 0.86 IRAK4 (0.44) PTGS2PTGS1IRAK4NR1H2NR1H3
SCHEMBL6171795 0.85 PTGS2 (0.51) PTGS2PTGS1NR1H2NR1H3
SCHEMBL6171652 0.83 IRAK4 (0.42) PTGS2PTGS1IRAK4NR1H2NR1H3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1015431-B1 2-AMINOPYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2 MERCK FROSST CANADA INC (CA) 2005-04-20 EP claimed
EP-1015431-A1 2-AMINOPYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2 Merck Frosst Canada & Co. (CA) 2000-07-05 EP claimed
WO-1999014195-A1 2-AMINOPYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2 MERCK FROSST CANADA & CO. (CA) 1999-03-25 WO claimed
EP-1015431-B1 2-AMINOPYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2 MERCK FROSST CANADA INC (CA) 2005-04-20 EP disclosed
EP-1015431-A1 2-AMINOPYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2 Merck Frosst Canada & Co. (CA) 2000-07-05 EP disclosed
US-6004950-A NON-STEROIDAL ANTIINFLAMMATORY AGENTS; ANALGESIC, ANTIPYRETICS; SIDE EFFECT REDUCTION MERCK FROSST CANADA, INC. (CA) 1999-12-21 US disclosed
WO-1999014195-A1 2-AMINOPYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2 MERCK FROSST CANADA & CO. (CA) 1999-03-25 WO disclosed