Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 2/20 | 0.36 |
| ▸ | MMP9 | P14780 | 2/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
| ▸ | MMP14 | P50281 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 5/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | ITGAV | P06756 | 1/20 | 0.32 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.32 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5130761 | 1.00 | MMP2 (0.36) | MMP2MMP9MMP8MMP12MMP14 | |
| SCHEMBL7395698 | 0.83 | ITGB3 (0.47) | MMP2MMP9MMP8MMP12MMP14 | |
| SCHEMBL11107976 | 0.78 | PMP22 (0.38) | ALDH1A1KMT2APMP22FOLH1MEN1 | |
| Hydrochloric Acid SCHEMBL11103201 | 0.77 | PMP22 (0.37) | ALDH1A1KMT2APMP22MEN1TSHR | |
| SCHEMBL26209690 | 0.75 | PMP22 (0.36) | MMP2MMP9ALDH1A1KMT2APMP22 | |
| SCHEMBL16750037 | 0.75 | PMP22 (0.36) | MMP2MMP9ALDH1A1KMT2APMP22 | |
| SCHEMBL7357439 | 0.74 | SLC1A3 (0.52) | MMP2MMP9MMP8ITGB3ITGA2B | |
| SCHEMBL1704473 | 0.73 | — | — | |
| SCHEMBL7401698 | 0.73 | ITGB3 (0.45) | MMP2MMP9MMP8MMP12MMP14 | |
| SCHEMBL12993547 | 0.73 | PMP22 (0.37) | ALDH1A1KMT2APMP22MEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534693-A2 | 1, 3-DIAMINO-2-HYDROXYPROPANE PRODRUG DERIVATIVES | Elan Pharmaceuticals, Inc. (US) | 2005-06-01 | — | — | EP | claimed |
| WO-2004022523-A2 | 1, 3-DIAMINO-2-HYDROXYPROPANE PRODRUG DERIVATIVES | ELAN PHARMACEUTICALS, INC. (US) | 2004-03-18 | — | — | WO | claimed |