Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CYP1A1 | P04798 | 8/20 | 0.44 |
| ▸ | CYP1B1 | Q16678 | 8/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6170951 | 1.00 | CFTR (0.55) | CFTRALDH1A1MAPTLMNAGAA | |
| SCHEMBL6170728 | 0.89 | CFTR (0.51) | CFTRALDH1A1MAPTLMNAGAA | |
| SCHEMBL6170732 | 0.89 | CFTR (0.51) | CFTRALDH1A1MAPTLMNAGAA | |
| SCHEMBL9493070 | 0.87 | ALDH1A1 (0.51) | CFTRALDH1A1MAPTLMNAGAA | |
| SCHEMBL9493078 | 0.87 | ALDH1A1 (0.51) | CFTRALDH1A1MAPTLMNAGAA | |
| SCHEMBL20671048 | 0.85 | ESR1 (0.52) | CFTRALDH1A1MAPTLMNAGAA | |
| SCHEMBL6821084 | 0.84 | CYP1A1 (0.53) | CFTRALDH1A1MAPTLMNAGAA | |
| SCHEMBL6821081 | 0.84 | CYP1A1 (0.53) | CFTRALDH1A1MAPTLMNAGAA | |
| SCHEMBL13675597 | 0.83 | CYP1A1 (0.49) | CFTRALDH1A1MAPTLMNAGAA | |
| SCHEMBL8120979 | 0.82 | ALDH1A1 (0.54) | CFTRALDH1A1MAPTGAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150353508-A1 | QUINOLINYL GLUCAGON RECEPTOR MODULATORS | PFIZER INC. (US) | 2015-12-10 | — | — | US | disclosed |
| US-20150353508-A1 | QUINOLINYL GLUCAGON RECEPTOR MODULATORS | PFIZER INC. (US) | 2015-12-10 | — | — | US | disclosed |
| US-20150353508-A1 | QUINOLINYL GLUCAGON RECEPTOR MODULATORS | PFIZER INC. (US) | 2015-12-10 | — | — | US | disclosed |
| US-9139538-B2 | Quinolinyl glucagon receptor modulators | PFIZER INC. (US) | 2015-09-22 | — | — | US | disclosed |
| US-9139538-B2 | Quinolinyl glucagon receptor modulators | PFIZER INC. (US) | 2015-09-22 | — | — | US | disclosed |
| US-9139538-B2 | Quinolinyl glucagon receptor modulators | PFIZER INC. (US) | 2015-09-22 | — | — | US | disclosed |
| EP-2734503-B1 | QUINOLINYL GLUCAGON RECEPTOR MODULATORS | PFIZER (US) | 2015-09-16 | — | — | EP | disclosed |
| EP-2734503-B1 | QUINOLINYL GLUCAGON RECEPTOR MODULATORS | PFIZER (US) | 2015-09-16 | — | — | EP | disclosed |
| CN-103732578-B | quinolinyl glucagon receptor modulators | PFIZER INC. (US) | 2015-08-12 | — | — | CN | disclosed |
| US-20150099882-A1 | QUINOLINYL GLUCAGON RECEPTOR MODULATORS | PFIZER INC. (US) | 2015-04-09 | — | — | US | disclosed |
| US-20140135338-A1 | QUINOLINYL GLUCAGON RECEPTOR MODULATORS | PFIZER INC. (US) | 2014-05-15 | — | — | US | disclosed |
| US-20140135338-A1 | QUINOLINYL GLUCAGON RECEPTOR MODULATORS | PFIZER INC. (US) | 2014-05-15 | — | — | US | disclosed |
| CN-103732578-A | Quinolinyl glucagon receptor modulators | PFIZER | 2014-04-16 | — | — | CN | disclosed |
| WO-2013014569-A1 | QUINOLINYL GLUCAGON RECEPTOR MODULATORS | PFIZER INC. (US) | 2013-01-31 | — | — | WO | disclosed |
| WO-2013014569-A1 | QUINOLINYL GLUCAGON RECEPTOR MODULATORS | PFIZER INC. (US) | 2013-01-31 | — | — | WO | disclosed |
| EP-1045833-B1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| US-6608070-B1 | Useful for treatment of medical condition in which prostaglandins are implicated as pathogens | NAKAO KAZUNARI (JP) | 2003-08-19 | — | — | US | disclosed |
| EP-1065206-B1 | Tetrazolylalkyl indole compounds as anti-inflammatory and analgesic agents | PFIZER (US) | 2002-10-09 | — | — | EP | disclosed |
| CN-1284064-A | 2,3-substituted indole compounds as cox-2 inhibitors | PFIZER PHARMA (US) | 2001-02-14 | — | — | CN | disclosed |
| EP-1065206-A1 | Tetrazolylalkyl indole compounds as anti-inflammatory and analgesic agents | PFIZER INC. (US) | 2001-01-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150099882-A1 | QUINOLINYL GLUCAGON RECEPTOR MODULATORS | GLP1R, GCGR, GPR119 | CFTR 125/4885ALDH1A1 3335/4885MAPT 4296/4885 |
| US-20150353508-A1 | QUINOLINYL GLUCAGON RECEPTOR MODULATORS | GLP1R, GCGR, GPR119 | CFTR 125/4885ALDH1A1 3335/4885MAPT 4296/4885 |
| US-20140135338-A1 | QUINOLINYL GLUCAGON RECEPTOR MODULATORS | GLP1R, GCGR, GPR119 | CFTR 125/4885ALDH1A1 3335/4885MAPT 4296/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.