Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | LIN28A | Q9H9Z2 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2187238 | 0.91 | L3MBTL1 (0.55) | TRPM8SMN1; SMN2MAPTLIN28ATDP1 | |
| SCHEMBL2189143 | 0.83 | TRPM8 (0.47) | TRPM8SMN1; SMN2MAPTLIN28ATDP1 | |
| SCHEMBL14260508 | 0.81 | TRPM8 (0.54) | TRPM8SMN1; SMN2MAPTLIN28ATDP1 | |
| SCHEMBL7169955 | 0.81 | TRPM8 (0.54) | TRPM8SMN1; SMN2MAPTLIN28ATDP1 | |
| SCHEMBL12204158 | 0.81 | TRPM8 (0.60) | TRPM8SMN1; SMN2MAPTLIN28ATDP1 | |
| SCHEMBL14544545 | 0.81 | TRPM8 (0.54) | TRPM8SMN1; SMN2MAPTLIN28ATDP1 | |
| SCHEMBL427048 | 0.79 | SMN1; SMN2 (0.52) | TRPM8SMN1; SMN2MAPTLIN28ATDP1 | |
| SCHEMBL27373373 | 0.79 | TRPM8 (0.58) | TRPM8SMN1; SMN2MAPTLIN28ATDP1 | |
| SCHEMBL27439189 | 0.79 | TRPM8 (0.55) | TRPM8SMN1; SMN2MAPTLIN28ATDP1 | |
| SCHEMBL28923770 | 0.79 | L3MBTL1 (0.60) | TRPM8SMN1; SMN2MAPTLIN28ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1332942-C | Sulfonylamino-acetic acid derivatives and their use as orexin receptor antagonists | ACTELION PHARMACEUTICALS LTD (CH) | 2007-08-22 | — | — | CN | disclosed |
| CN-1703397-A | Sulfonylamino-acetic acid derivatives and their use as orexin receptor antagonists | ACTELION PHARMACEUTICALS LTD (CH) | 2005-11-30 | — | — | CN | disclosed |
| EP-1554239-A2 | SULFONYLAMINO-ACETIC ACID DERIVATIVES AND THEIR USE AS OREXIN RECEPTOR ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004033418-A2 | SULFONYLAMINO-ACETIC DERIVATIVES AND THEIR USE AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD. (CH) | 2004-04-22 | — | — | WO | disclosed |