SCHEMBL6171190

SCHEMBL6171190

CS(=O)(=O)OC(CCc1ccccc1)C(=O)O

nearest known ligand 0.52

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
PPARG P37231 8/20 0.52
PPARA Q07869 6/20 0.52
CYP24A1 Q07973 1/20 0.47
BLM P54132 1/20 0.47
TSHR P16473 1/20 0.44
SRR Q9GZT4 2/20 0.44
ACE P12821 1/20 0.43
PTGES O14684 1/20 0.42
ALOX5 P09917 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6171187 1.00 PPARG (0.52) PPARGPPARACYP24A1BLMTSHR
SCHEMBL4224537 0.85 SMN1; SMN2 (0.49) PPARGPPARACYP24A1ACE
SCHEMBL18063399 0.84 BLM (0.61) PPARGPPARABLMSRR
SCHEMBL6903818 0.84 PPARG (0.52) PPARGPPARABLMSRRACE
SCHEMBL6438045 0.83 SRR (0.59) PPARGPPARASRRACE
SCHEMBL6438277 0.83 SRR (0.59) PPARGPPARASRRACE
SCHEMBL6907074 0.83 PPARG (0.49) PPARGPPARABLMTSHRACE
SCHEMBL6903829 0.83 PPARG (0.49) PPARGPPARABLMTSHRSRR
SCHEMBL7495011 0.83 PPARG (0.61) PPARGPPARATSHRSRRACE
SCHEMBL27130395 0.82 HTT (0.42) PPARGPPARATSHRSRR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2005281246-A METHOD FOR PRODUCTION OF CILAZAPRIL KONICA MINOLTA CHEMICAL CO LTD 2005-10-13 JP disclosed
EP-1098885-B9 IMIDAZOLE COMPOUNDS AND THEIR USE AS ADENOSINE DEAMINASE INHIBITORS FUJISAWA PHARMACEUTICAL CO (JP) 2005-05-18 EP disclosed
EP-1098885-B1 IMIDAZOLE COMPOUNDS AND THEIR USE AS ADENOSINE DEAMINASE INHIBITORS FUJISAWA PHARMACEUTICAL CO (JP) 2004-11-17 EP disclosed
US-6359145-B1 ADENOSINE DEAMINASE INHIBITOR; ANTIINFLAMMATORY AGENTS; IMMUNOSUPPRESSANT FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2002-03-19 US disclosed
EP-1098885-A1 IMIDAZOLE COMPOUNDS AND THEIR USE AS ADENOSINE DEAMINASE INHIBITORS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-05-16 EP disclosed
WO-2001026605-A2 IMMUNOSUPPRESSIVE COMPOSITION CONTAINING IL-2 INHIBITOR AND AN ADENOSINE DEAMINASE INHIBITOR FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-04-19 WO disclosed
WO-2000005217-A1 IMIDAZOLE COMPOUNDS AND THEIR USE AS ADENOSINE DEAMINASE INHIBITORS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2000-02-03 WO disclosed
EP-0657446-B1 Process for producing optically active erythro-3-amino-1,2-epoxy compound NIPPON KAYAKU KK (JP) 1998-05-13 EP disclosed
US-5488118-A Process for producing optically active erythro-3-amino-1,2-epoxy compound NIPPON KAYAKU KABUSHIKI KAISHA (JP) 1996-01-30 US disclosed
EP-0657446-A1 Process for producing optically active erythro-3-amino-1,2-epoxy compound NIPPON KAYAKU KABUSHIKI KAISHA (JP) 1995-06-14 EP disclosed