Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CCR2 | P41597 | 5/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6173018 | 0.88 | CCR9 (0.37) | KDM4EGAATSHRCYP1A2CYP3A4 | |
| SCHEMBL6174225 | 0.85 | MAPT (0.42) | IGF1RGAACYP2C9CCR2KMT2A | |
| SCHEMBL6174113 | 0.85 | IGF1R (0.40) | IGF1RGAACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6174555 | 0.84 | IGF1R (0.40) | IGF1RGAACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6176685 | 0.84 | IGF1R (0.39) | IGF1RGAACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL2936600 | 0.83 | IGF1R (0.57) | IGF1RKDM4EGAATSHRCYP1A2 | |
| SCHEMBL6173238 | 0.83 | IGF1R (0.41) | IGF1RKDM4EKMT2AALDH1A1TP53 | |
| SCHEMBL6174148 | 0.82 | IGF1R (0.40) | IGF1RKDM4EGAACYP3A4CYP2C9 | |
| SCHEMBL6176020 | 0.82 | IGF1R (0.40) | IGF1RGAACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6175985 | 0.80 | IGF1R (0.41) | IGF1RGAACYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |