Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.69 |
| ▸ | MME | P08473 | 3/20 | 0.67 |
| ▸ | ACE | P12821 | 2/20 | 0.62 |
| ▸ | ECE1 | P42892 | 1/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6172205 | 1.00 | LTA4H (0.69) | LTA4HMMEACEECE1ALOX15 | |
| SCHEMBL11430738 | 0.94 | ACE (0.67) | LTA4HMMEACEECE1ALOX15 | |
| SCHEMBL6171219 | 0.93 | MME (0.71) | LTA4HMMEACEECE1ALOX15 | |
| SCHEMBL7323834 | 0.91 | LTA4H (0.58) | LTA4HMME | |
| SCHEMBL7323829 | 0.91 | LTA4H (0.58) | LTA4HMME | |
| SCHEMBL7323825 | 0.91 | LTA4H (0.58) | LTA4HMME | |
| SCHEMBL6169855 | 0.91 | LTA4H (0.59) | LTA4HMMEACEECE1 | |
| SCHEMBL6171860 | 0.91 | LTA4H (0.61) | LTA4HMMEACEECE1ALOX15 | |
| SCHEMBL9068531 | 0.89 | ECE1 (0.75) | ACEECE1ALOX15 | |
| SCHEMBL6171453 | 0.89 | LTA4H (0.68) | LTA4HMMEACEECE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888341-B1 | NOVEL SULPHUR DERIVATIVES COMPRISING AN AMIDE BOND, METHOD FOR PREPARING SAME, USE THEREOF AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH DERIVATIVES | AVENTIS PHARMA SA (FR) | 2005-11-30 | — | — | EP | disclosed |
| US-6136842-A | INHIBITION OF ENDOTHELIN-CONVERTING ENZYME | HOECHST MARION ROUSSEL (FR) | 2000-10-24 | — | — | US | disclosed |
| EP-0888341-A1 | NOVEL SULPHUR DERIVATIVES COMPRISING AN AMIDE BOND, METHOD FOR PREPARING SAME, USE THEREOF AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH DERIVATIVES | HOECHST MARION ROUSSEL (FR) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997032874-A1 | NOVEL SULPHUR DERIVATIVES COMPRISING AN AMIDE BOND, METHOD FOR PREPARING SAME, USE THEREOF AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH DERIVATIVES | HOECHST MARION ROUSSEL (FR) | 1997-09-12 | — | — | WO | disclosed |