Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 6/20 | 0.75 |
| ▸ | ACE | P12821 | 2/20 | 0.64 |
| ▸ | MMP2 | P08253 | 5/20 | 0.64 |
| ▸ | MMP9 | P14780 | 4/20 | 0.64 |
| ▸ | MMP8 | P22894 | 4/20 | 0.64 |
| ▸ | MMP1 | P03956 | 2/20 | 0.64 |
| ▸ | ANPEP | P15144 | 1/20 | 0.60 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.60 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.59 |
| ▸ | ADAM12 | O43184 | 1/20 | 0.59 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.59 |
| ▸ | MMP3 | P08254 | 1/20 | 0.59 |
| ▸ | MMP7 | P09237 | 1/20 | 0.59 |
| ▸ | MMP12 | P39900 | 1/20 | 0.59 |
| ▸ | MMP13 | P45452 | 1/20 | 0.59 |
| ▸ | MMP14 | P50281 | 1/20 | 0.59 |
| ▸ | MMP15 | P51511 | 1/20 | 0.59 |
| ▸ | MMP16 | P51512 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11430738 | 0.93 | ACE (0.67) | ECE1ACEALOX15 | |
| SCHEMBL7322267 | 0.90 | ACE (0.73) | ECE1ACEALOX15 | |
| SCHEMBL6172205 | 0.89 | LTA4H (0.69) | ECE1ACEALOX15 | |
| SCHEMBL6172199 | 0.89 | LTA4H (0.69) | ECE1ACEALOX15 | |
| SCHEMBL6575025 | 0.86 | MMP2 (0.85) | ECE1ACEMMP2MMP9MMP8 | |
| SCHEMBL9068557 | 0.86 | ECE1 (1.00) | ECE1ACE | |
| SCHEMBL4795667 | 0.86 | MMP2 (0.85) | ECE1ACEMMP2MMP9MMP8 | |
| SCHEMBL6171219 | 0.85 | MME (0.71) | ECE1ACEALOX15 | |
| SCHEMBL6431194 | 0.85 | ECE1 (0.79) | ECE1ACEMMP2MMP9MMP8 | |
| SCHEMBL31036126 | 0.85 | ECE1 (0.79) | ECE1ACEMMP2MMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5496805-A | DIURETIC, HYPOTENSIVE | E. R. SQUIBB & SONS, INC. (US) | 1996-03-05 | — | — | US | disclosed |