Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 12/20 | 0.42 |
| ▸ | AR | P10275 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6174954 | 0.91 | IGF1R (0.40) | IGF1RARKMT2AMEN1TSHR | |
| SCHEMBL6173106 | 0.88 | IGF1R (0.48) | IGF1RARKMT2A | |
| SCHEMBL6173508 | 0.87 | IGF1R (0.56) | IGF1RAR | |
| SCHEMBL17558394 | 0.87 | AR (0.41) | IGF1RARKMT2AMEN1TSHR | |
| SCHEMBL6177138 | 0.85 | AR (0.40) | IGF1RARKMT2AMEN1TSHR | |
| SCHEMBL6174561 | 0.80 | IGF1R (0.40) | IGF1RARKMT2ATSHR | |
| SCHEMBL6169038 | 0.79 | IGF1R (0.39) | IGF1RARKMT2AMEN1TSHR | |
| SCHEMBL6173711 | 0.77 | IGF1R (0.59) | IGF1R | |
| SCHEMBL6176345 | 0.77 | IGF1R (0.53) | IGF1RAR | |
| SCHEMBL6175543 | 0.76 | IGF1R (0.56) | IGF1RAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3188729-A1 | CYCLIC UREA COMPOUNDS AS TROPOMYOSIN-RELATED KINASE (TRK) INHIBITORS | Genzyme Corporation (US) | 2017-07-12 | — | — | EP | disclosed |
| WO-2016036796-A1 | CYCLIC UREA COMPOUNDS AS TROPOMYOSIN-RELATED KINASE (TRK) INHIBITORS | GENZYME CORPORATION (US) | 2016-03-10 | — | — | WO | disclosed |
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |