Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 9/20 | 0.41 |
| ▸ | IGF1R | P08069 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6177138 | 0.91 | AR (0.40) | ARIGF1RMEN1KMT2ALMNA | |
| SCHEMBL6174954 | 0.89 | IGF1R (0.40) | ARIGF1RMEN1KMT2ALMNA | |
| SCHEMBL6173683 | 0.87 | IGF1R (0.52) | ARIGF1R | |
| SCHEMBL6172298 | 0.87 | IGF1R (0.42) | ARIGF1RMEN1KMT2ATSHR | |
| SCHEMBL6173106 | 0.82 | IGF1R (0.48) | ARIGF1RKMT2ACYP3A4CYP2C9 | |
| SCHEMBL6173212 | 0.80 | ADRB3 (0.40) | ARIGF1RCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6201343 | 0.79 | PTGS2 (0.40) | ARIGF1RMEN1KMT2ALMNA | |
| SCHEMBL2932588 | 0.77 | AR (0.67) | ARIGF1RMEN1KMT2ALMNA | |
| SCHEMBL6172820 | 0.77 | IGF1R (0.42) | ARIGF1R | |
| SCHEMBL6174494 | 0.77 | IGF1R (0.42) | ARIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3188729-A1 | CYCLIC UREA COMPOUNDS AS TROPOMYOSIN-RELATED KINASE (TRK) INHIBITORS | Genzyme Corporation (US) | 2017-07-12 | — | — | EP | disclosed |
| WO-2016036796-A1 | CYCLIC UREA COMPOUNDS AS TROPOMYOSIN-RELATED KINASE (TRK) INHIBITORS | GENZYME CORPORATION (US) | 2016-03-10 | — | — | WO | disclosed |