Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.47 |
| ▸ | C5 | P01031 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MAP2 | P11137 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.41 |
| ▸ | TUBB | P07437 | 1/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.41 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.41 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.41 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6172663 | 0.93 | HPGD (0.47) | PTGS2MAPTPTGS1MEN1ABCC4 | |
| SCHEMBL6170865 | 0.91 | MAP2 (0.52) | PTGS2MAPTPTGS1MEN1ABCC4 | |
| SCHEMBL6171537 | 0.91 | PTGS2 (0.53) | PTGS2MAPTPTGS1MEN1ABCC4 | |
| SCHEMBL6172994 | 0.90 | PTGS2 (0.46) | PTGS2MAPTPTGS1MEN1ABCC4 | |
| SCHEMBL7205524 | 0.89 | MDM2 (0.47) | PTGS2MAPTPTGS1MEN1ABCC4 | |
| SCHEMBL6174354 | 0.88 | MEN1 (0.52) | PTGS2MAPTPTGS1MEN1ABCC4 | |
| SCHEMBL6172076 | 0.87 | PTGS2 (0.50) | PTGS2MAPTPTGS1MEN1ABCC4 | |
| SCHEMBL6171863 | 0.87 | PTGS2 (0.50) | PTGS2MAPTPTGS1MEN1ABCC4 | |
| SCHEMBL6171552 | 0.87 | PTGS2 (0.44) | PTGS2MAPTPTGS1MEN1ABCC4 | |
| SCHEMBL6168997 | 0.87 | PTGS2 (0.52) | PTGS2MAPTPTGS1MEN1ABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045833-B1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2005-11-02 | — | — | EP | claimed |
| US-6608070-B1 | Useful for treatment of medical condition in which prostaglandins are implicated as pathogens | NAKAO KAZUNARI (JP) | 2003-08-19 | — | — | US | claimed |
| US-6608070-B1 | Useful for treatment of medical condition in which prostaglandins are implicated as pathogens | NAKAO KAZUNARI (JP) | 2003-08-19 | — | — | US | disclosed |