Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 4/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.46 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.46 |
| ▸ | C5 | P01031 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6168997 | 0.90 | PTGS2 (0.52) | MDM2CYP3A4PTGS2MEN1KMT2A | |
| SCHEMBL6172503 | 0.89 | PTGS2 (0.47) | MDM2PTGS2MEN1KMT2APTGS1 | |
| SCHEMBL6171537 | 0.89 | PTGS2 (0.53) | MDM2PTGS2MEN1KMT2APTGS1 | |
| SCHEMBL6172994 | 0.88 | PTGS2 (0.46) | PTGS2MEN1KMT2APTGS1ABCC4 | |
| SCHEMBL6172482 | 0.88 | PTGS2 (0.48) | MDM2PTGS2MEN1KMT2APTGS1 | |
| SCHEMBL6173031 | 0.87 | MDM2 (0.51) | MDM2MCL1 | |
| SCHEMBL6172076 | 0.85 | PTGS2 (0.50) | PTGS2MEN1KMT2APTGS1ABCC4 | |
| SCHEMBL6171863 | 0.85 | PTGS2 (0.50) | MDM2PTGS2MEN1KMT2APTGS1 | |
| SCHEMBL6171552 | 0.85 | PTGS2 (0.44) | CYP1A2CYP2C9PTGS2MEN1KMT2A | |
| SCHEMBL6172663 | 0.85 | HPGD (0.47) | POLBPTGS2MEN1KMT2APTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6608070-B1 | Useful for treatment of medical condition in which prostaglandins are implicated as pathogens | NAKAO KAZUNARI (JP) | 2003-08-19 | — | — | US | claimed |
| US-6608070-B1 | Useful for treatment of medical condition in which prostaglandins are implicated as pathogens | NAKAO KAZUNARI (JP) | 2003-08-19 | — | — | US | disclosed |