Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.46 |
| ▸ | C5 | P01031 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6171537 | 0.90 | PTGS2 (0.53) | PTGS2PTGS1MEN1ABCC4C5 | |
| SCHEMBL6171863 | 0.86 | PTGS2 (0.50) | PTGS2PTGS1MEN1ABCC4C5 | |
| SCHEMBL6172076 | 0.86 | PTGS2 (0.50) | PTGS2PTGS1MEN1ABCC4C5 | |
| SCHEMBL6172018 | 0.86 | PTGS2 (0.44) | PTGS2PTGS1MEN1ABCC4C5 | |
| SCHEMBL6168997 | 0.86 | PTGS2 (0.52) | PTGS2PTGS1MEN1ABCC4C5 | |
| SCHEMBL6172482 | 0.84 | PTGS2 (0.48) | PTGS2PTGS1MEN1ABCC4C5 | |
| SCHEMBL6171310 | 0.84 | PTGS2 (0.46) | PTGS2PTGS1MEN1ABCC4C5 | |
| SCHEMBL6172503 | 0.83 | PTGS2 (0.47) | PTGS2PTGS1MEN1ABCC4C5 | |
| SCHEMBL6172166 | 0.83 | PTGS2 (0.49) | PTGS2PTGS1MEN1ABCC4C5 | |
| SCHEMBL6172994 | 0.83 | PTGS2 (0.46) | PTGS2PTGS1MEN1ABCC4C5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045833-B1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2005-11-02 | — | — | EP | claimed |
| US-6608070-B1 | Useful for treatment of medical condition in which prostaglandins are implicated as pathogens | NAKAO KAZUNARI (JP) | 2003-08-19 | — | — | US | claimed |
| US-6608070-B1 | Useful for treatment of medical condition in which prostaglandins are implicated as pathogens | NAKAO KAZUNARI (JP) | 2003-08-19 | — | — | US | disclosed |