Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 10/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6172548 | 0.82 | EPHX2 (0.38) | — | |
| SCHEMBL6172595 | 0.82 | EPHX2 (0.38) | — | |
| SCHEMBL6172455 | 0.75 | SLC6A2 (0.36) | SLC6A2RIPK1SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL4749383 | 0.71 | OPRM1 (0.44) | CYP2D6 | |
| SCHEMBL2117103 | 0.71 | SLC6A2 (0.36) | SLC6A2SLC6A4HTR2C | |
| SCHEMBL6182513 | 0.64 | SLC6A2 (0.32) | SLC6A2RIPK1MAOBSLC6A4HTT | |
| SCHEMBL16252050 | 0.64 | SLC6A2 (0.49) | SLC6A2SLC6A4SLC6A3CYP2D6HTR2C | |
| SCHEMBL4397153 | 0.64 | RECQL (0.48) | SLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL2477280 | 0.64 | SLC6A2 (0.47) | SLC6A2MAOBSLC6A4SLC6A3CYP2D6 | |
| SCHEMBL5790811 | 0.64 | SIGMAR1 (0.61) | HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569934-A2 | CYCLOPROPYL COMPOUNDS AS CCR5 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-09-07 | — | — | EP | disclosed |
| WO-2004055010-A2 | CYCLOPROPYL COMPOUNDS AS CCR5 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-07-01 | — | — | WO | disclosed |